2-Methoxyestradiol

CAS 362-07-2C19H26O3Biochemicals & Reagents

2-Methoxyestradiol (CAS: 362-07-2), with the molecular formula C19H26O3 and a molar mass of 302.41 g/mol, is a naturally occurring catechol estrogen metabolite. It is recognised for its potent anti-angiogenic and anti-proliferative properties, making it a subject of interest in cancer research. This compound serves as a valuable biochemical tool for investigating cellular processes related to tumour growth and vascularisation.

IUPAC: 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether,2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether,2-Hydroxyestradiol 2-methyl ether,3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene

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2-Methoxyestradiol (C19H26O3) — chemical structure, CAS 362-07-2; Life Science, fine chemical supplied by Tech Serve Solutions

AngiogenesisAngiogenesis InhibitorsAnti-proliferative AgentsBioactive Small MoleculesBiochemicals and ReagentsCancer ResearchCell BiologyChemopreventive AgentsCytokinesGrowth Factors and Hormones

01 /Applications

Cancer Research

2-Methoxyestradiol is investigated for its potential anti-tumour activities, particularly its ability to inhibit angiogenesis and cell proliferation in various cancer models.

Angiogenesis Studies

As a known angiogenesis inhibitor, this compound is utilised in research to understand the mechanisms of new blood vessel formation, a critical process in both physiological and pathological conditions like cancer and rheumatoid arthritis.

Cell Biology Research

This molecule serves as a probe in cell biology to study cell division, apoptosis, and the role of estrogen metabolism in cellular functions and signaling pathways.

Biochemical Reagent

Used as a biochemical reagent in laboratories, 2-Methoxyestradiol aids in a variety of research applications requiring well-defined biologically active molecules.

02 /Properties

Molecular weight	302.41
Empirical formula	C19H26O3
Form	powder
Colour	white to faint yellow
Solubility	DMSO: soluble10 mg/mLethanol: soluble10 mg/mLH2O: insoluble

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged exposure
H410Very toxic to aquatic life with long-lasting effects

Precautionary statements

P201Obtain special instructions before use
P261Avoid breathing dust, fume, gas or vapours
P273Avoid release to the environment
P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T,N
Risk statements (R)	45-46-60-61-23/24/25-36/37/38-48-51/53
Safety statements (S)	53-22-26-36/37/39-45-61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

362-07-2

MDL number

MFCD00010489

PubChem substance

24278561

05 /Additional specifications

Gene Information	human ... ESR1(2099), ESR2(2100)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is 2-Methoxyestradiol used for?

2-Methoxyestradiol is primarily used in research for its anti-angiogenic and anti-proliferative properties, particularly in cancer research and cell biology studies.

What is the CAS number and formula for 2-Methoxyestradiol?

The CAS number is 362-07-2 and the empirical formula is C19H26O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2-Methoxyestradiol as a white to faint yellow powder. The exact purity is typically ≥98%. This product is intended for research and laboratory use only and is not supplied as USP, BP, EP, or pharmaceutical grade.

What are the primary safety hazards associated with 2-Methoxyestradiol?

2-Methoxyestradiol is classified as toxic if swallowed, in contact with skin, or if inhaled (H301 + H311 + H331). It is also a skin irritant (H315), eye irritant (H319), and may cause respiratory irritation (H335). Furthermore, it is suspected of causing cancer (H350) and may damage fertility or the unborn child (H360), and can cause damage to organs through prolonged or repeated exposure (H372). It is also very toxic to aquatic life with long lasting effects (H410). Handle with appropriate personal protective equipment including eyeshields, gloves, and a respirator.

How is 2-Methoxyestradiol packed and shipped?

2-Methoxyestradiol is supplied as a powder and is packed securely for safe transport. Tech Serve Solutions is experienced in exporting chemicals globally, adhering to all necessary regulations for international shipment.

How can I request a quote or sample for 2-Methoxyestradiol?

To request a quote or a sample, please visit our website or contact our sales team directly. Provide the product name (2-Methoxyestradiol) and CAS number (362-07-2) for prompt service.