2-Methoxy-5-(trifluoromethyl)aniline
2-Methoxy-5-(trifluoromethyl)aniline (CAS: 349-65-5) is a specialised organic compound with the molecular formula C8H8F3NO. This aniline derivative, featuring a trifluoromethyl group and a methoxy substituent, serves as a valuable building block in organic synthesis. It is primarily utilised in the chemical industry for the development of new molecules and as an intermediate in the preparation of more complex chemical structures. TSS supplies this compound for research and industrial applications.
- IUPAC
- 6-Methoxy-α,α,α-trifluoro-m-toluidine

Organic Synthesis Intermediate
2-Methoxy-5-(trifluoromethyl)aniline is employed as a key intermediate in the synthesis of various organic compounds. Its functional groups allow for diverse chemical transformations, making it useful in multi-step synthetic routes.
Pharmaceutical Research
This compound can be used in the research and development of novel pharmaceutical agents. The trifluoromethyl group can influence lipophilicity and metabolic stability, properties often sought in drug discovery.
Agrochemical Development
It may serve as a precursor in the synthesis of new agrochemicals. The presence of fluorine and nitrogen moieties can contribute to the biological activity of derived compounds.
Material Science
This aniline derivative can be incorporated into polymers or other materials where its specific electronic or structural properties are advantageous.
| Molecular weight | 191.15 |
|---|---|
| Linear formula | CH3OC6H3(CF3)NH2 |
| Assay | 96% |
| Melting point | 58-60 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxy-5-(trifluoromethyl)aniline used for?
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2-Methoxy-5-(trifluoromethyl)aniline is primarily used as a building block and intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and potentially advanced materials.
What is the CAS number and molecular formula for 2-Methoxy-5-(trifluoromethyl)aniline?
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The CAS number is 349-65-5 and the molecular formula is CH3OC6H3(CF3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methoxy-5-(trifluoromethyl)aniline with an assay of 96%. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 2-Methoxy-5-(trifluoromethyl)aniline be handled safely?
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Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash skin thoroughly after handling. It is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and may cause respiratory irritation.
How is 2-Methoxy-5-(trifluoromethyl)aniline packed and exported?
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2-Methoxy-5-(trifluoromethyl)aniline is carefully packed according to industry standards for safe transport and is exported globally by TSS.
How can I request a quote or sample?
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To request a quote or a sample of 2-Methoxy-5-(trifluoromethyl)aniline, please contact our sales team through the TSS website or by phone.
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