2-Iodobenzyl chloride
2-Iodobenzyl chloride (CAS: 59473-45-9, Formula: IC6H4CH2Cl, MW: 252.48) is a halogenated hydrocarbon utilized as a key building block in organic synthesis. Its structure, featuring both an iodine atom and a benzyl chloride moiety, allows for diverse chemical transformations. This compound serves as a valuable intermediate in the preparation of more complex molecules, particularly within pharmaceutical research and fine chemical manufacturing.
Synthesis of Indane Derivatives
2-Iodobenzyl chloride is employed in the synthesis of succinimido[3,4-b]indane, a fused ring system with potential applications in medicinal chemistry.
Preparation of Benzazocine Structures
It has been utilized in the preparation of 1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine-2,4-dione, a complex heterocyclic scaffold relevant to drug discovery.
Formation of Substituted Amines
The compound serves as a precursor for various N-alkylated amines, including substituted pyrrolidines, piperidines, morpholines, and piperazines, through reactions with corresponding secondary amines.
Indole Functionalization
2-Iodobenzyl chloride can be used to introduce the 2-iodobenzyl group onto indole, facilitating the synthesis of 1-(2-iodobenzyl)indole-2-carbaldehyde.
| Molecular weight | 252.48 |
|---|---|
| Linear formula | IC6H4CH2Cl |
| Assay | 98% |
| Boiling point | 147-149 °C/32 mmHg(lit.) |
| Refractive index | n20/D 1.635(lit.) |
| Application | 2-Iodobenzyl chloride was used in the synthesis of:• succinimido[3,4-b]indane1• 1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine-2,4-dione1• 1-(2-iodobenzyi)-1,1-diethylamine2• 1-(2-iodobenzyl)pyrrolidine2• 1-(2-iodobenzyl)piperidine2• 1-(2-iodobenzyl)hexahydroazepine2• 4-(2-iodobenzyl)morpholine2• 4-(2-iodobenzyl)thiomorpholine2• 1-benzoyl-4-(2-iodobenzyl)piperazine2• 1-(2-iodobenzyl)indole-2-carbaldehyde2 |
| Melting point | 29-31 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Iodobenzyl chloride used for?
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2-Iodobenzyl chloride is used as a building block in organic synthesis for the preparation of various complex molecules, including indane derivatives, benzazocine structures, substituted amines, and functionalized indoles.
What are the CAS number and chemical formula for 2-Iodobenzyl chloride?
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The CAS number for 2-Iodobenzyl chloride is 59473-45-9, and its chemical formula is IC6H4CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Iodobenzyl chloride with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Iodobenzyl chloride be handled safely?
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2-Iodobenzyl chloride is classified as Danger, causing severe skin burns and eye damage, and may cause respiratory irritation (H314-H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection, must be used. Handle only in well-ventilated areas.
Is 2-Iodobenzyl chloride a controlled substance?
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The provided data does not indicate that 2-Iodobenzyl chloride is a controlled substance.
How is 2-Iodobenzyl chloride packed, shipped, and exported?
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2-Iodobenzyl chloride is shipped as UN 3261, Hazard Class 8, Packing Group II. Specific packaging and export details can be provided upon request.
How can I request a quote or sample of 2-Iodobenzyl chloride?
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Please contact our sales team to request a quote or sample of 2-Iodobenzyl chloride. Our team will be happy to assist you with your specific requirements.
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