2-Iodoanisole
2-Iodoanisole (CAS: 529-28-2), with the molecular formula C7H7IO and a molar mass of 234.03 g/mol, is a valuable organic building block. This aryl halide is an ether derivative of anisole, featuring an iodine atom ortho to the methoxy group. It is primarily employed in organic synthesis, particularly in metal-catalysed cross-coupling reactions and the preparation of complex organic molecules. Its characteristic properties make it a useful reagent in various chemical research and development applications.
- IUPAC
- 2-Iodophenyl methyl ether,2-Methoxyiodobenzene
- Synonyms
- 2-Iodophenyl methyl ether2-Methoxyiodobenzene
Organic Synthesis Intermediate
2-Iodoanisole serves as a key intermediate in the synthesis of various organic compounds. Its aryl iodide functionality is reactive in cross-coupling reactions, enabling the formation of new carbon-carbon or carbon-heteroatom bonds.
Preparation of Substituted Aromatics
It is utilised in the preparation of ortho-substituted anisole derivatives. For example, it has been employed in palladium/copper-catalysed synthesis of o-(1-alkynyl)anisoles, offering a pathway to complex aromatic structures.
Research and Development
As a functionalised aromatic compound, 2-Iodoanisole is a useful reagent in academic and industrial research laboratories for exploring novel synthetic routes and developing new chemical entities.
| Molecular weight | 234.03 |
|---|---|
| Linear formula | IC6H4OCH3 |
| Assay | 98% |
| Boiling point | 125-126 °C/19 mmHg(lit.) |
| Density | 1.799 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.622(lit.) |
| Solubility | alcohol: miscible(lit.)chloroform: miscible(lit.)diethyl ether: miscible(lit.)water: insoluble(lit.) |
| Application | 2-Iodoanisole has been used in palladium/copper-catalyzed synthesis of o-(1-alkynyl)anisoles1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Iodoanisole used for?
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2-Iodoanisole is primarily used as an intermediate in organic synthesis, particularly in palladium/copper-catalysed reactions for the preparation of substituted aromatic compounds like o-(1-alkynyl)anisoles. It is a useful building block for chemical research and development.
What is the CAS number and formula for 2-Iodoanisole?
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The CAS number for 2-Iodoanisole is 529-28-2, and its linear formula is C7H7IO.
What grade and purity does Tech Serve Solutions supply for 2-Iodoanisole?
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Tech Serve Solutions supplies 2-Iodoanisole with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should 2-Iodoanisole be handled safely?
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2-Iodoanisole is classified with warning signal word and hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, such as eyeshields, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area.
How is 2-Iodoanisole typically packed and shipped?
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2-Iodoanisole is carefully packed to ensure safe transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical substances.
How can I request a sample or quote for 2-Iodoanisole?
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To request a sample or a quotation for 2-Iodoanisole, please contact our sales department through the website or by email, providing your specific requirements.
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