2-Hydroxy-4-methoxybenzoic acid
2-Hydroxy-4-methoxybenzoic acid (CAS 2237-36-7), with the molecular formula C8H8O4 and a molar mass of 168.15 g/mol, is a valuable organic compound. Also known as 4-methoxysalicylic acid, this chemical serves as a crucial building block in various synthetic processes. It is primarily utilised in the development of organic molecules, including advanced pharmaceutical intermediates and novel chemical entities.
- IUPAC
- 4-Methoxysalicylic acid

Synthesis of Heterocyclic Compounds
2-Hydroxy-4-methoxybenzoic acid is employed as a precursor in the synthesis of heterocyclic compounds. For instance, it has been used in the preparation of 1,3,4-oxadiazole derivatives, which are scaffolds found in many biologically active molecules.
Organic Synthesis Building Block
This compound functions as a versatile building block in organic chemistry. Its structure, featuring both a hydroxyl and a carboxylic acid group alongside a methoxy substituent, allows for diverse chemical transformations.
Research and Development
It is utilised in research laboratories for exploring new synthetic routes and developing novel organic materials. Its availability facilitates academic and industrial research in medicinal chemistry and material science.
| Molecular weight | 168.15 |
|---|---|
| Linear formula | CH3OC6H3(OH)CO2H |
| Assay | 99% |
| Application | 2-Hydroxy-4-methoxybenzoic acid (4-methoxysalicylic acid) was used in the synthesis of 1,3,4-oxadiazole derivatives1. |
| Melting point | 158-159 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Hydroxy-4-methoxybenzoic acid used for?
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2-Hydroxy-4-methoxybenzoic acid is used as a building block in organic synthesis, notably in the preparation of heterocyclic compounds such as 1,3,4-oxadiazole derivatives, and for general research and development in chemistry.
What are the CAS number and molecular formula for 2-Hydroxy-4-methoxybenzoic acid?
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The CAS number for 2-Hydroxy-4-methoxybenzoic acid is 2237-36-7, and its molecular formula is C8H8O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Hydroxy-4-methoxybenzoic acid with a purity of 99%. This product is suitable for research and chemical synthesis purposes. TSS does not represent this product as USP, BP, EP, or pharmaceutical grade.
What are the primary hazards associated with 2-Hydroxy-4-methoxybenzoic acid?
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2-Hydroxy-4-methoxybenzoic acid is classified with the GHS07 symbol and the signal word 'Warning'. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (N95), should be used during handling.
How is 2-Hydroxy-4-methoxybenzoic acid packed, shipped, and exported?
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2-Hydroxy-4-methoxybenzoic acid is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for 2-Hydroxy-4-methoxybenzoic acid?
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To request a sample or a quote for 2-Hydroxy-4-methoxybenzoic acid, please contact the Tech Serve Solutions sales team through our website or by phone.
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