2-Fluoro-6-nitrotoluene
2-Fluoro-6-nitrotoluene (CAS 769-10-8), with the molecular formula CH3C6H3(NO2)F and a molecular weight of 155.13 g/mol, is a specialised organic compound. It serves as a valuable building block in chemical synthesis, particularly for introducing fluorinated and nitrated aromatic moieties. This compound is noted for its application in preparing indole derivatives, contributing to the development of diverse chemical structures.
Synthesis of Indole Derivatives
2-Fluoro-6-nitrotoluene is utilized in the Leimgruber-Batcho procedure for the preparation of 4-fluoroindole. This highlights its utility in constructing complex heterocyclic systems important in medicinal chemistry and materials science.
Fluorinated Building Block
As a fluorinated aromatic compound, it functions as a versatile building block in organic synthesis. The presence of both fluorine and nitro substituents allows for various synthetic transformations.
Organic Synthesis Intermediate
This chemical is employed as an intermediate in multi-step syntheses, enabling the introduction of specific functional groups into target molecules. Its reactivity profile makes it suitable for diverse chemical research and development.
| Molecular weight | 155.13 |
|---|---|
| Linear formula | CH3C6H3(NO2)F |
| Assay | 98% |
| Boiling point | 97 °C/11 mmHg(lit.) |
| Density | 1.27 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.523(lit.) |
| Application | 2-Fluoro-6-nitrotoluene has been used in the preparation of 4-fluoroindole via Leimgruber-Batcho procedure1. |
| Melting point | 6.5-7 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 89 °C / 192.2 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-6-nitrotoluene used for?
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2-Fluoro-6-nitrotoluene is used as a building block in organic synthesis, notably in the preparation of indole derivatives via the Leimgruber-Batcho procedure.
What is the CAS number and formula for 2-Fluoro-6-nitrotoluene?
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The CAS number for 2-Fluoro-6-nitrotoluene is 769-10-8, and its chemical formula is CH3C6H3(NO2)F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoro-6-nitrotoluene with an assay of 98%. This is a research-grade material and is not represented as USP, BP, or EP.
How should 2-Fluoro-6-nitrotoluene be handled safely?
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2-Fluoro-6-nitrotoluene is a warning substance (GHS07) and may cause harm if swallowed, in contact with skin, or if inhaled. It also causes skin and serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be used. Handle in a well-ventilated area. Refer to the safety data sheet for comprehensive guidance.
Is 2-Fluoro-6-nitrotoluene a controlled substance?
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The provided data does not indicate that 2-Fluoro-6-nitrotoluene is a controlled substance.
How is 2-Fluoro-6-nitrotoluene packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and shipping for 2-Fluoro-6-nitrotoluene, adhering to all relevant regulations for chemical transport worldwide.
How can I request a sample or quote for 2-Fluoro-6-nitrotoluene?
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To request a sample or quote for 2-Fluoro-6-nitrotoluene, please contact our sales department through the website or by phone, providing your specific requirements.
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