2-ethynylthiophene
2-Ethynylthiophene (CAS: 4298-52-6), a thiophene derivative with the chemical formula C6H4S and a molecular weight of 108.16 g/mol, serves as a valuable heterocyclic building block in organic synthesis. Its reactive ethynyl group allows for versatile chemical transformations, making it a key intermediate for constructing more complex molecules. This compound is primarily utilised in chemical research and development, contributing to the advancement of novel materials and pharmaceuticals.
- IUPAC
- 2-Acetylenylthiophene
- Synonyms
- 2-Acetylenylthiophene

Organic Synthesis Intermediate
2-Ethynylthiophene acts as a foundational component in multi-step organic syntheses. Its terminal alkyne functionality readily participates in coupling reactions, cycloadditions, and functional group interconversions to build complex molecular architectures.
Pharmaceutical Research
This thiophene derivative is employed in medicinal chemistry for the development of novel pharmaceutical agents. Its incorporation into target molecules can influence pharmacokinetic properties and biological activity.
Materials Science
The compound can be a precursor in the synthesis of conjugated polymers and organic electronic materials. The thiophene ring and ethynyl group contribute to unique electronic and optical properties.
| Molecular weight | 108.16 |
|---|---|
| Empirical formula | C6H4S |
| Assay | 90% |
| Density | 1.139 g/mL at 25 °C |
| Refractive index | n20/D 1.580 |
| Storage temperature | −20°C |

Hazard statements
- H226Flammable liquid and vapour
| Flash point | 42 °C / 107.6 °F |
|---|---|
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Ethynylthiophene used for?
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2-Ethynylthiophene is primarily used as a building block in organic synthesis, particularly in the fields of pharmaceutical research and materials science for creating complex molecules and functional materials.
What is the CAS number and formula for 2-Ethynylthiophene?
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The CAS number for 2-Ethynylthiophene is 4298-52-6, and its chemical formula is C6H4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Ethynylthiophene with a minimum assay of 90%. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeial standards; it is suitable for research and technical applications.
How should 2-Ethynylthiophene be handled safely?
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2-Ethynylthiophene is a flammable liquid and vapour (H226). Handle with care in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment. Store at -20°C as indicated.
How is 2-Ethynylthiophene packed and shipped?
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2-Ethynylthiophene is packed and shipped according to relevant transportation regulations (UN 1993, Class 3, PGIII). Tech Serve Solutions exports globally, ensuring compliance with international shipping standards.
How can I request a quote or sample for 2-Ethynylthiophene?
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To request a quote or sample for 2-Ethynylthiophene, please contact our sales department via the website or direct inquiry, providing your specific requirements and delivery details.
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