2-Cyanothioacetamide
2-Cyanothioacetamide (CAS: 7357-70-2), with the molecular formula NCCH₂CSNH₂, is a versatile organic building block and sulfur compound. This chemical is instrumental in the synthesis of various heterocyclic compounds, particularly those containing pyridine and thiolate moieties. Its reactivity makes it a valuable intermediate in organic synthesis, contributing to the creation of complex molecules for research and development purposes.
Synthesis of Tetrahydropyridine Derivatives
2-Cyanothioacetamide is employed in the synthesis of 3,4-trans-4-aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates, highlighting its utility in constructing complex nitrogen and sulfur-containing heterocycles.
Preparation of Bis[2-thioxo-1,2-dihydropyridine-3-carbonitrile] Compounds
This compound serves as a precursor for bis[6-(2-aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile] structures, demonstrating its role in forming fused ring systems.
Building Block for 2-Pyridothiones
2-Cyanothioacetamide is a key intermediate in the preparation of various 2-pyridothione derivatives, which are significant scaffolds in medicinal chemistry and materials science.
| Molecular weight | 100.14 |
|---|---|
| Linear formula | NCCH2CSNH2 |
| Assay | 97% |
| Application | 2-Cyanothioacetamide was used in the synthesis of 3,4-trans-4-aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates1 and bis[6-(2-aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile]2. It was also used as a building block for 2-pyridothiones3,4. |
| Melting point | 118-120 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3439 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Cyanothioacetamide used for?
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2-Cyanothioacetamide is primarily used as a building block in organic synthesis for creating complex heterocyclic compounds such as tetrahydropyridine derivatives, bis[2-thioxo-1,2-dihydropyridine-3-carbonitrile] compounds, and 2-pyridothiones.
What are the CAS number and chemical formula for 2-Cyanothioacetamide?
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The CAS number for 2-Cyanothioacetamide is 7357-70-2, and its linear chemical formula is NCCH₂CSNH₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Cyanothioacetamide with an assay of 97%. This is a research-grade chemical and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Cyanothioacetamide be handled safely?
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2-Cyanothioacetamide is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
Is 2-Cyanothioacetamide a controlled substance?
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The provided data does not indicate that 2-Cyanothioacetamide is a controlled substance.
How is 2-Cyanothioacetamide packed, shipped, and exported?
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2-Cyanothioacetamide is shipped under UN 3439, Class 6.1, Packing Group III. Tech Serve Solutions adheres to all relevant regulations for the safe packing, shipping, and international export of this chemical.
How can I request a sample or quote for 2-Cyanothioacetamide?
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To request a sample or a quote for 2-Cyanothioacetamide, please contact our sales department through the website or by phone, referencing the product name and CAS number (7357-70-2).
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