(2-Chloroethoxy)benzene
(2-Chloroethoxy)benzene (CAS: 622-86-6) is an organic ether with the molecular formula C6H5OCH2CH2Cl and a molecular weight of 156.61 g/mol. This compound functions as a valuable building block in organic synthesis. Its primary documented use involves participating in coupling reactions for the creation of pseudo-symmetrical tamoxifen derivatives, contributing to advancements in chemical synthesis research and development.
- IUPAC
- β-Chlorophenetole,2-Chloroethyl phenyl ether
Synthesis of Tamoxifen Derivatives
(2-Chloroethoxy)benzene is employed in coupling reactions involving benzaldehyde and cinnamyltrimethylsilane. This application is key in the synthesis of pseudo-symmetrical tamoxifen derivatives, contributing to research in medicinal chemistry.
Organic Synthesis Intermediate
As a functionalised ether, this compound serves as a versatile intermediate in various organic synthesis pathways. Its structure allows for further chemical modifications, making it useful for building more complex molecules.
Building Block for Complex Molecules
This chemical is classified as an organic building block, suitable for incorporation into larger molecular structures. Its utility spans diverse areas of chemical synthesis, facilitating the development of novel compounds.
| Molecular weight | 156.61 |
|---|---|
| Linear formula | C6H5OCH2CH2Cl |
| Assay | 98% |
| Boiling point | 97-98 °C/15 mmHg(lit.) |
| Density | 1.129 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.534(lit.) |
| Application | (2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2-Chloroethoxy)benzene primarily used for?
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(2-Chloroethoxy)benzene is primarily used in organic synthesis, notably in coupling reactions for the preparation of pseudo-symmetrical tamoxifen derivatives. It also serves as a general building block in chemical synthesis.
What are the CAS number and molecular formula for (2-Chloroethoxy)benzene?
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The CAS number for (2-Chloroethoxy)benzene is 622-86-6, and its molecular formula is C6H5OCH2CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (2-Chloroethoxy)benzene with a minimum purity of 98%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and industrial purposes.
How should (2-Chloroethoxy)benzene be handled safely?
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(2-Chloroethoxy)benzene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be used. Ensure adequate ventilation and use a suitable respirator if necessary.
How is (2-Chloroethoxy)benzene packed and shipped?
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(2-Chloroethoxy)benzene is carefully packed and prepared for domestic and international export by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical substances.
How can I request a quote or sample for (2-Chloroethoxy)benzene?
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To request a quote or sample of (2-Chloroethoxy)benzene, please contact our sales team through the website or by phone, providing your contact details and quantity requirements.
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