2-Chloro-N,N-dimethylacetamide
2-Chloro-N,N-dimethylacetamide (CAS 2675-89-0), also known as N,N-dimethylchloroacetamide, is an organic compound with the linear formula ClCH₂CON(CH₃)₂ and a molecular weight of 121.57 g/mol. This chemical serves as a valuable building block in organic synthesis. It is characterised by its role in the preparation of various complex molecules, including pharmaceutical intermediates. TSS supplies this compound with a minimum assay of 97.0%.
- IUPAC
- N,N-Dimethylchloroacetamide
- Synonyms
- ClCH2CON(CH3)2N,N-Dimethylchloroacetamide
Synthesis of Pharmaceutical Intermediates
2-Chloro-N,N-dimethylacetamide is utilised as a key intermediate in the synthesis of active pharmaceutical ingredients. A notable application includes its use in the preparation of (S)-carbinoxamine, a widely used antihistamine.
Organic Building Block
As a functionalised amide, this compound is a versatile building block in general organic synthesis. Its reactive chlorine atom allows for various nucleophilic substitution reactions, enabling the construction of more complex molecular structures.
Research and Development
This chemical is employed in research laboratories for developing new synthetic routes and novel compounds. Its availability facilitates exploration in medicinal chemistry and materials science.
| Molecular weight | 121.57 |
|---|---|
| Linear formula | ClCH2CON(CH3)2 |
| Assay | ≥97.0% (GC) |
| Density | 1.182 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.479 |
| Application | 2-Chloro-N,N-dimethylacetamide (N,N-dimethylchloroacetamide) was used in the synthesis of (S)-carbinoxamine1. |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-N,N-dimethylacetamide primarily used for?
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2-Chloro-N,N-dimethylacetamide is primarily used as a building block in organic synthesis, notably in the preparation of pharmaceutical intermediates such as (S)-carbinoxamine.
What is the CAS number and linear formula for 2-Chloro-N,N-dimethylacetamide?
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The CAS number is 2675-89-0 and the linear formula is ClCH₂CON(CH₃)₂.
What grade and purity does Tech Serve Solutions supply for 2-Chloro-N,N-dimethylacetamide?
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Tech Serve Solutions supplies 2-Chloro-N,N-dimethylacetamide with a minimum assay of 97.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should 2-Chloro-N,N-dimethylacetamide be handled safely?
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2-Chloro-N,N-dimethylacetamide is classified as corrosive and harmful if swallowed. Handling requires appropriate personal protective equipment, including gloves, goggles, and a suitable respirator, and should be performed in a well-ventilated area. Refer to the Safety Data Sheet for detailed information.
Is 2-Chloro-N,N-dimethylacetamide available for export globally?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 2-Chloro-N,N-dimethylacetamide, adhering to all international shipping regulations.
How can I request a quote or sample for 2-Chloro-N,N-dimethylacetamide?
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To request a quote or a sample, please contact our sales team through the website or by calling our office. Please specify the quantity and intended use.
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