2-Chloro-5-(trifluoromethyl)phenylboronic acid

CAS 182344-18-9C7H5BClF3O2Chemical Synthesis

2-Chloro-5-(trifluoromethyl)phenylboronic acid (CAS: 182344-18-9) is a crucial organoborane compound with the molecular formula C7H5BClF3O2 and a molecular weight of 224.37 g/mol. It is widely employed as a building block in organic synthesis, particularly in cross-coupling reactions for the development of complex molecules. Its structure allows for versatile chemical transformations, making it valuable in pharmaceutical research and materials science.

IUPAC: 2-Chloro-5-(trifluoromethyl)benzeneboronic acid

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2-Chloro-5-(trifluoromethyl)phenylboronic acid (C7H5BClF3O2) — chemical structure, CAS 182344-18-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Organic Synthesis Reagent

This boronic acid derivative serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions. It facilitates the formation of carbon-carbon bonds, essential for constructing intricate organic structures used in drug discovery and fine chemical manufacturing.

Pharmaceutical Intermediate

Utilized in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates. Its trifluoromethyl and chloro substituents offer specific electronic and steric properties beneficial for medicinal chemistry applications.

Materials Science

Can be incorporated into the design and synthesis of novel organic materials, such as those used in electronic devices or advanced polymers, owing to its unique structural features.

02 /Properties

Molecular weight	224.37
Empirical formula	C7H5BClF3O2
Application	May contain varying amounts of anhydride.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Transport (UN / ADR)	UN 3335
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

182344-18-9

MDL number

MFCD00797335

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-Chloro-5-(trifluoromethyl)phenylboronic acid used for?

2-Chloro-5-(trifluoromethyl)phenylboronic acid is primarily used as a reagent in organic synthesis, especially in Suzuki-Miyaura cross-coupling reactions, for the creation of complex organic molecules relevant to pharmaceutical and materials science research.

What are the CAS number and formula for this compound?

The CAS number for 2-Chloro-5-(trifluoromethyl)phenylboronic acid is 182344-18-9 and its empirical formula is C7H5BClF3O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound as a research-grade chemical. The specific assay or purity is detailed in the product specifications. We do not represent it as USP, BP, or EP grade.

What are the main safety hazards associated with this chemical?

This compound is classified as a Warning (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used.

How is this chemical shipped and exported?

This chemical is shipped and exported according to international regulations for hazardous materials. It is classified under UN 3335 for transport.

How can I request a sample or a quote?

To request a sample or a quote for 2-Chloro-5-(trifluoromethyl)phenylboronic acid, please contact our sales department through the website or by phone, providing your requirements and shipping details.