2-Chloro-3-(trifluoromethyl)pyridine
2-Chloro-3-(trifluoromethyl)pyridine (CAS: 65753-47-1), with the molecular formula C6H3ClF3N and a molecular weight of 181.54 g/mol, is a halogenated pyridine derivative. This chemical serves as a valuable building block in organic synthesis, particularly within the pharmaceutical and agrochemical industries. Its unique structure, featuring both a chlorine atom and a trifluoromethyl group on the pyridine ring, enables diverse chemical transformations for the development of novel compounds.

Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs) due to its trifluoromethyl pyridine core, which can impart desirable pharmacological properties.
Agrochemical Development
Acts as a key intermediate in the production of herbicides, insecticides, and fungicides, contributing to the development of advanced crop protection agents.
Material Science Research
Explored for its potential use in the creation of novel materials where fluorinated heterocyclic compounds are required for specific electronic or physical properties.
Organic Synthesis Reagent
Serves as a versatile building block for introducing the 3-(trifluoromethyl)pyridyl moiety into complex organic molecules.
| Molecular weight | 181.54 |
|---|---|
| Empirical formula | C6H3ClF3N |
| Assay | 97% |
| Melting point | 36-40 °C(lit.) |


Hazard statements
- H228Flammable solid
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 82 °C / 179.6 °F |
| Transport (UN / ADR) | UN 2926 4.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-25-36/37/38 |
| Safety statements (S) | 16-22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-(trifluoromethyl)pyridine used for?
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2-Chloro-3-(trifluoromethyl)pyridine (CAS: 65753-47-1) is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. It enables the introduction of a trifluoromethyl pyridine moiety into target molecules.
What are the CAS number and molecular formula of 2-Chloro-3-(trifluoromethyl)pyridine?
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The CAS number for 2-Chloro-3-(trifluoromethyl)pyridine is 65753-47-1, and its molecular formula is C6H3ClF3N.
What grade and purity does Tech Serve Solutions supply for 2-Chloro-3-(trifluoromethyl)pyridine?
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Tech Serve Solutions supplies 2-Chloro-3-(trifluoromethyl)pyridine with a minimum assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 2-Chloro-3-(trifluoromethyl)pyridine be handled safely?
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2-Chloro-3-(trifluoromethyl)pyridine is a flammable solid and is acutely toxic if swallowed. It is also irritating to the skin, eyes, and respiratory tract. Handling requires appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, and should be performed in a well-ventilated area, away from ignition sources.
Is 2-Chloro-3-(trifluoromethyl)pyridine packed and shipped internationally by TSS?
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Yes, Tech Serve Solutions, as a specialist global supplier and exporter since 1998, packs and exports 2-Chloro-3-(trifluoromethyl)pyridine, adhering to all necessary regulations for international shipping.
How can I request a quote or sample for 2-Chloro-3-(trifluoromethyl)pyridine?
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To request a quote or a sample of 2-Chloro-3-(trifluoromethyl)pyridine, please use the contact form on our website or reach out to our sales department directly.
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