2-Chloro-3-cyano-4-pyridinylboronic acid pinacol ester
2-Chloro-3-cyano-4-pyridinylboronic acid pinacol ester (CAS 878194-94-6) is a heteroaryl boronate ester with the empirical formula C12H14BClN2O2 and a molecular weight of 264.52 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. Its structure makes it useful for introducing functionalised pyridine moieties into complex organic molecules, finding applications in pharmaceutical research and materials science.
- IUPAC
- 2-Chloro-3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Suzuki-Miyaura Coupling Reagent
This boronate ester is primarily employed as a coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of complex biaryl compounds and substituted pyridines.
Pharmaceutical Intermediate
The compound is utilised in the synthesis pathways of potential pharmaceutical agents. Its pyridine core, functionalised with chloro, cyano, and boronate ester groups, allows for diverse molecular modifications.
Organic Synthesis Building Block
As a versatile organometallic reagent, it is instrumental in constructing novel heterocyclic frameworks for use in medicinal chemistry and the development of advanced materials.
| Molecular weight | 264.52 |
|---|---|
| Empirical formula | C12H14BClN2O2 |
| Assay | 95% |
| Storage temperature | −20°C |
| Melting point | 90-97 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 2 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-cyano-4-pyridinylboronic acid pinacol ester used for?
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This compound is used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds and the construction of complex molecules, often in pharmaceutical research.
What is the CAS number and formula for this product?
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The CAS number is 878194-94-6 and the empirical formula is C12H14BClN2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a minimum purity of 95%. This is a research or technical grade material and TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
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This compound is a Warning substance, classified with H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/eye protection/face protection. If in eyes, rinse cautiously with water for several minutes.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions securely packs chemicals according to international shipping regulations. We are experienced global exporters, ensuring compliant and safe transit of laboratory reagents and fine chemicals worldwide.
How can I request a quote or sample?
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To request a quote or a sample, please use the 'Contact Us' form on our website or call our sales department. Please include the product name and CAS number in your request.
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