2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate
2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate (CAS: 153433-26-2) is a versatile reagent with the molecular formula C5H10BClF4N2 and a molecular weight of 220.40 g/mol. It is principally employed in chemical synthesis, particularly for esterification and peptide coupling, even with sterically hindered amino acids. Its utility extends to preparing diazo-transfer reagents and serving as a precursor in the synthesis of palladium and nickel catalysts for coupling reactions.
- IUPAC
- CIB
- Synonyms
- C5H10BClF4N2
Peptide Synthesis
This reagent facilitates the esterification and peptide coupling of sterically hindered amino acids, a common challenge in peptide chemistry. Its effectiveness aids in the formation of amide bonds under demanding conditions.
Diazo-Transfer Reagent Preparation
It serves as a key intermediate in the preparation of efficient diazo-transfer reagents. These reagents are crucial for introducing the diazo group into organic molecules, a valuable transformation in synthetic organic chemistry.
Catalyst Synthesis
The compound is utilised in oxidative insertion reactions for synthesising palladium and nickel catalysts. These catalysts are essential for a variety of coupling reactions, enabling efficient carbon-carbon and carbon-heteroatom bond formation.
| Molecular weight | 220.40 |
|---|---|
| Empirical formula | C5H10BClF4N2 |
| Assay | ≥95.0% (AT) |
| Solubility | acetonitrile: soluble0.1 g/mL, clear |
| Storage temperature | 2-8°C |
| Application | Reagent for: Esterification and peptide coupling of sterically hindered amino acids1 Preparation of efficient diazo-transfer reagents2 Oxidative insertion for palladium and nickel catalyst synthesis3 Preparation of catalysts for use in coupling reactions4 |
| Melting point | 175-177 °C(lit.)175-178 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate used for?
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2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate is used as a reagent for esterification and peptide coupling of sterically hindered amino acids, for preparing efficient diazo-transfer reagents, and for oxidative insertion in palladium and nickel catalyst synthesis for coupling reactions.
What is the CAS number and molecular formula for 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate?
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The CAS number is 153433-26-2, and the molecular formula is C5H10BClF4N2.
What grade and purity does Tech Serve Solutions supply for 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate?
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Tech Serve Solutions supplies this compound with an assay of ≥95.0% (AT). We do not represent it as USP, BP, EP, or pharmacopoeia grade.
How should 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate be handled safely?
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This compound is classified as causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves in a well-ventilated area.
How is 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate shipped and exported?
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Tech Serve Solutions, a global supplier and exporter since 1998, ships and exports fine chemicals worldwide, adhering to all relevant regulations for safe and compliant transport.
How can I request a quote or sample for 2-Chloro-1,3-dimethylimidazolidinium tetrafluoroborate?
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Please contact our sales team via the website or email to request a quote or a sample. Provide the product name and CAS number for prompt service.
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