(2-Chloro-1,1,2-trifluoroethyl)diethylamine
(2-Chloro-1,1,2-trifluoroethyl)diethylamine (CAS 357-83-5) is a fluorinated organic building block with the molecular formula C6H11ClF3N and a molecular weight of 189.61 g/mol. This compound serves as a valuable intermediate in chemical synthesis, particularly for introducing fluorinated moieties into complex organic molecules. Its unique structure makes it suitable for research and development in pharmaceuticals and materials science.
- IUPAC
- N,N-Diethyl-2-chloro-1,1,2-trifluoroethylamine,Yarovenko′s Reagent
- Synonyms
- 357-83-5C6H11ClF3NN,N-Diethyl-2-chloro-1,1,2-trifluoroethylamineYarovenko′s Reagent

Fluorinated Intermediate
Serves as a key intermediate for the synthesis of more complex fluorinated organic compounds. It is utilised in research and development settings for creating novel molecules.
Building Block in Organic Synthesis
This compound functions as a versatile building block in organic synthesis, enabling the introduction of a trifluoroethyl group. Its reactivity is beneficial in the construction of diverse molecular architectures.
Pharmaceutical Research
Used in the exploration of new pharmaceutical agents where fluorination can impart desirable properties such as enhanced metabolic stability or lipophilicity. Its application is primarily in early-stage R&D.
| Molecular weight | 189.61 |
|---|---|
| Empirical formula | C6H11ClF3N |
| Assay | 97% |
| Density | 1.205 g/mL at 25 °C |
| Refractive index | n20/D 1.396 |
| Storage temperature | 2-8°C |


Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | 50 °C / 122 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2-Chloro-1,1,2-trifluoroethyl)diethylamine used for?
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(2-Chloro-1,1,2-trifluoroethyl)diethylamine is used as an intermediate and building block in organic synthesis, particularly for introducing fluorinated groups in pharmaceutical research and materials science.
What is the CAS number and formula for (2-Chloro-1,1,2-trifluoroethyl)diethylamine?
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The CAS number is 357-83-5 and the empirical formula is C6H11ClF3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (2-Chloro-1,1,2-trifluoroethyl)diethylamine with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling (2-Chloro-1,1,2-trifluoroethyl)diethylamine?
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This compound is a flammable liquid and causes severe skin burns and eye damage (H226-H314). Handle with appropriate personal protective equipment in a well-ventilated area, avoiding ignition sources. Refer to the Safety Data Sheet for comprehensive guidance.
How is (2-Chloro-1,1,2-trifluoroethyl)diethylamine packed, shipped, and exported?
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Products are packed securely according to international shipping regulations. Tech Serve Solutions is a global supplier and exporter, adhering to all relevant export compliance for chemical substances.
How can I request a sample or quote for (2-Chloro-1,1,2-trifluoroethyl)diethylamine?
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To request a sample or a quotation, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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