2-Bromo-6-methoxynaphthalene
2-Bromo-6-methoxynaphthalene (CAS: 5111-65-9), a brominated aromatic ether with the formula BrC10H6OCH3 and a molecular weight of 237.09 g/mol, serves as a valuable building block in organic synthesis. Its primary application lies in the chemical industry for the production of more complex molecules, notably as an intermediate in the synthesis of pharmaceuticals like nabumetone, an anti-inflammatory drug. This compound is supplied by TSS with an assay of 97%.
Synthesis of Nabumetone
2-Bromo-6-methoxynaphthalene is a key precursor in the synthesis of nabumetone, a non-steroidal anti-inflammatory drug (NSAID). Its role in forming the naphthyl moiety of nabumetone is typically achieved through reactions like the Heck reaction.
Organic Building Block
This compound functions as a versatile building block in organic chemistry. The presence of both a bromine atom and a methoxy group on the naphthalene ring allows for diverse synthetic transformations, enabling the construction of various complex organic structures.
Pharmaceutical Intermediate
Beyond nabumetone, 2-Bromo-6-methoxynaphthalene can be employed in the synthesis of other pharmaceutical agents or their advanced intermediates. Its specific structural features are amenable to further functionalization required in drug discovery and development.
| Molecular weight | 237.09 |
|---|---|
| Linear formula | BrC10H6OCH3 |
| Assay | 97% |
| Application | 2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction1. |
| Melting point | 106-109 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-6-methoxynaphthalene used for?
+
2-Bromo-6-methoxynaphthalene is primarily used as a building block in organic synthesis, particularly as an intermediate in the production of pharmaceuticals such as nabumetone.
What are the CAS number and chemical formula for 2-Bromo-6-methoxynaphthalene?
+
The CAS number for 2-Bromo-6-methoxynaphthalene is 5111-65-9, and its chemical formula is BrC10H6OCH3.
What grade and purity does Tech Serve Solutions supply for 2-Bromo-6-methoxynaphthalene?
+
Tech Serve Solutions supplies 2-Bromo-6-methoxynaphthalene with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Bromo-6-methoxynaphthalene be handled safely?
+
Based on GHS information, 2-Bromo-6-methoxynaphthalene is harmful if swallowed (H302) and requires appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
Can Tech Serve Solutions export 2-Bromo-6-methoxynaphthalene?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Bromo-6-methoxynaphthalene, and can facilitate international shipments.
How can I request a quote or sample of 2-Bromo-6-methoxynaphthalene?
+
To request a quote or a sample of 2-Bromo-6-methoxynaphthalene, please contact the TSS sales department through the website or by phone, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis