2-Bromo-6-fluorophenylboronic acid MIDA ester
2-Bromo-6-fluorophenylboronic acid MIDA ester (CAS: 1257650-76-2) is a valuable organometallic reagent used in advanced organic synthesis. With a molecular weight of 329.91 g/mol, this compound serves as a key building block in cross-coupling reactions, particularly Suzuki couplings, owing to the stable MIDA ester protecting group. Its specific structure facilitates the introduction of the 2-bromo-6-fluorophenyl moiety into complex molecular architectures.
Suzuki Cross-Coupling Reactions
This MIDA boronate ester is an effective coupling partner in Suzuki-Miyaura cross-coupling reactions. It enables the formation of carbon-carbon bonds by reacting with aryl or vinyl halides and pseudohalides, facilitated by palladium catalysis.
Synthesis of Pharmaceutical Intermediates
The compound is employed in the synthesis of complex organic molecules, including intermediates for active pharmaceutical ingredients (APIs). Its structure allows for precise incorporation of functionalised aromatic rings.
Material Science Applications
It can be utilised in the development of novel organic materials where specific aryl functionalities are required for tuning electronic or optical properties.
| Molecular weight | 329.91 |
|---|---|
| Empirical formula | C11H10BBrFNO4 |
| Assay | 97% |
| Application | Suzuki Cross-Coupling with MIDA Boronates |
| Melting point | 214-218 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-6-fluorophenylboronic acid MIDA ester used for?
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2-Bromo-6-fluorophenylboronic acid MIDA ester is primarily used as a building block in organic synthesis, especially for Suzuki cross-coupling reactions, and in the preparation of pharmaceutical intermediates and novel organic materials.
What is the CAS number and empirical formula?
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The CAS number is 1257650-76-2 and the empirical formula is C11H10BBrFNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-6-fluorophenylboronic acid MIDA ester at a purity of 97%. We do not represent this product as USP, BP, or EP grade.
How should this chemical be handled?
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This compound may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Bromo-6-fluorophenylboronic acid MIDA ester. Please contact us for export availability and shipping details.
How can I request a quote or sample?
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To request a quote or a sample of 2-Bromo-6-fluorophenylboronic acid MIDA ester, please use the contact form on our website or contact our sales team directly.
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