2-Bromo-5-(trifluoromethyl)pyridine
2-Bromo-5-(trifluoromethyl)pyridine (CAS 50488-42-1), with the molecular formula C6H3BrF3N and a molecular weight of 225.99 g/mol, is a halogenated heterocyclic compound. It serves as a key building block in organic synthesis, particularly in the development of complex molecules. Its primary known application involves its use as a substrate in palladium-catalyzed α-arylation reactions.
Organic Synthesis Intermediate
This compound is valuable in organic chemistry as a versatile building block. It facilitates the introduction of the trifluoromethylpyridine moiety into larger molecular structures, enabling the synthesis of novel organic compounds.
Palladium-Catalyzed Reactions
It functions as a substrate in palladium-catalyzed cross-coupling reactions. Specifically, it has been utilised in the α-arylation of a Reformatsky reagent, a common method for carbon-carbon bond formation.
Pharmaceutical and Agrochemical Research
The trifluoromethylpyridine scaffold is present in various biologically active molecules, making 2-Bromo-5-(trifluoromethyl)pyridine a relevant intermediate in the research and development of new pharmaceuticals and agrochemicals.
| Molecular weight | 225.99 |
|---|---|
| Empirical formula | C6H3BrF3N |
| Assay | 97% |
| Application | Substrate used in a palladium-catalyzed α-arylation of a Refomatsky reagent.1 |
| Melting point | 44-48 °C |
Hazard statements
- H300Fatal if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P264Wash thoroughly after handling
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-5-(trifluoromethyl)pyridine used for?
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2-Bromo-5-(trifluoromethyl)pyridine (CAS 50488-42-1) is primarily used as a building block in organic synthesis, notably as a substrate in palladium-catalyzed α-arylation reactions.
What are the CAS number and formula for 2-Bromo-5-(trifluoromethyl)pyridine?
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The CAS number for 2-Bromo-5-(trifluoromethyl)pyridine is 50488-42-1, and its empirical formula is C6H3BrF3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-5-(trifluoromethyl)pyridine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 2-Bromo-5-(trifluoromethyl)pyridine be handled safely?
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This compound is classified as acutely toxic if swallowed and causes skin and serious eye irritation, with potential respiratory irritation. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, is recommended. Handle in a well-ventilated area and avoid dust formation.
Is 2-Bromo-5-(trifluoromethyl)pyridine shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Bromo-5-(trifluoromethyl)pyridine.
How can I request a quote or sample?
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To request a quote or a sample of 2-Bromo-5-(trifluoromethyl)pyridine, please contact our sales team through the website or via direct inquiry.
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