2-Bromo-4-methylbenzaldehyde
2-Bromo-4-methylbenzaldehyde (CAS: 824-54-4) is an aromatic aldehyde with the chemical formula Br(CH3)C6H3CHO and a molecular weight of 199.04 g/mol. This technical grade compound serves as a valuable building block in organic synthesis. It participates in a range of chemical transformations, including coupling reactions, condensation, and cyclization processes, making it a key intermediate for the synthesis of more complex organic molecules.
- IUPAC
- 2-bromo-p-tolualdehyde
Carbonylative Coupling Reactions
This aldehyde is employed as a reactant in carbonylative Stille couplings, which can be followed by isomerization and intramolecular Heck reactions to construct intricate molecular architectures.
Knoevenagel Condensation
2-Bromo-4-methylbenzaldehyde participates in Knoevenagel condensation reactions, a versatile method for forming carbon-carbon double bonds, essential in many synthetic pathways.
Heterocycle Synthesis
The compound is utilised in cyclization reactions, including the cyclization of N-(α-methyl-p-methoxybenzyl)-imino-esters and imination followed by oxidative heterocyclization and carbonylation, yielding various heterocyclic systems.
Hydroacylation Reactions
It serves as a substrate in intermolecular and intramolecular hydroacylation of alkenes, a direct method for introducing carbonyl groups adjacent to double bonds.
| Molecular weight | 199.04 |
|---|---|
| Linear formula | Br(CH3)C6H3CHO |
| Grade | technical grade |
| Application | Reactant involved in:• Carbonylative Stille couplings followed by isomerization and intramolecular Heck reactions1• Knoevenagel condensation2• Cyclization of N-(α-methyl-p-methoxybenzyl)-imino-esters3• Imination and oxidative heterocyclization / carbonylation4• Intramolecular amination5• Intermolecular and intramolecular hydroacylation of alkenes by aromatic aldehydes6 |
| Melting point | 30-35 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-4-methylbenzaldehyde used for?
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2-Bromo-4-methylbenzaldehyde is primarily used as a reactant and building block in organic synthesis, participating in various reactions like carbonylative couplings, Knoevenagel condensation, cyclizations, and hydroacylation.
What is the CAS number and chemical formula for 2-Bromo-4-methylbenzaldehyde?
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The CAS number for 2-Bromo-4-methylbenzaldehyde is 824-54-4, and its chemical formula is Br(CH3)C6H3CHO.
What grade and purity does Tech Serve Solutions supply for 2-Bromo-4-methylbenzaldehyde?
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Tech Serve Solutions supplies 2-Bromo-4-methylbenzaldehyde in technical grade. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for 2-Bromo-4-methylbenzaldehyde?
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2-Bromo-4-methylbenzaldehyde is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is 2-Bromo-4-methylbenzaldehyde packed, shipped, and exported?
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2-Bromo-4-methylbenzaldehyde is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions.
How can I request a sample or a quote for 2-Bromo-4-methylbenzaldehyde?
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To request a sample or a quote for 2-Bromo-4-methylbenzaldehyde, please contact our sales department through the website or by phone.
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