2-Aminothiophene-3-carbonitrile
2-Aminothiophene-3-carbonitrile (CAS: 4651-82-5, C5H4N2S) is a heterocyclic organic compound with a molecular weight of 124.16 g/mol. It serves as a valuable building block in organic synthesis, particularly for the construction of more complex thiophene derivatives and other heterocyclic systems. Its utility is recognised in research and development across various chemical synthesis pathways.

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of diverse organic molecules. Its structure readily participates in reactions to form fused ring systems and substituted thiophenes, important in medicinal chemistry and materials science.
Heterocyclic Chemistry
Serves as a foundational component for constructing novel heterocyclic compounds. The presence of both amine and nitrile functionalities on the thiophene ring allows for versatile derivatisation.
Pharmaceutical Research
Employed in the early stages of drug discovery and development, where thiophene-containing scaffolds are explored for potential therapeutic properties. Its role is primarily as a synthetic precursor.
| Molecular weight | 124.16 |
|---|---|
| Empirical formula | C5H4N2S |
| Assay | 97% |
| Melting point | 104-108 °C |


Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Aminothiophene-3-carbonitrile used for?
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2-Aminothiophene-3-carbonitrile (CAS: 4651-82-5) is used as a versatile building block in organic synthesis, particularly for creating complex heterocyclic compounds and thiophene derivatives.
What is the CAS number and formula for 2-Aminothiophene-3-carbonitrile?
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The CAS number is 4651-82-5, and the empirical formula is C5H4N2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Aminothiophene-3-carbonitrile with a minimum assay of 97%. This product is intended for research and technical use; TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should 2-Aminothiophene-3-carbonitrile be handled?
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Danger: Harmful if swallowed, causes skin irritation, causes serious eye damage, and may cause respiratory irritation. Handle with appropriate personal protective equipment including a dust mask (type N95 or equivalent), eyeshields, face shield, and gloves. Ensure adequate ventilation.
How is this chemical shipped?
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Tech Serve Solutions exports chemicals globally. Packaging is suitable for safe transport and handling according to international regulations. Please contact us for specific export inquiries.
How can I request a sample or quote?
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To request a sample or a quotation for 2-Aminothiophene-3-carbonitrile, please use the contact form on our website or email our sales department directly, providing your details and requirements.
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