2-Amino-5-bromopyrazine
2-Amino-5-bromopyrazine (CAS 59489-71-3) is a halogenated heterocyclic compound with the molecular formula C4H4BrN3 and a molecular weight of 174.00 g/mol. This pyrazine derivative serves as a valuable building block in organic synthesis. It is particularly noted for its utility in palladium-catalyzed cross-coupling reactions, enabling the efficient synthesis of complex molecules, including pyrazinylpyridines, without requiring prior protection of the amino group.
Palladium-Catalyzed Cross-Coupling
This compound is effectively employed in palladium-catalyzed cross-coupling reactions. It facilitates the synthesis of pyrazinylpyridines through coupling with pyridylboronic acids.
Heterocyclic Synthesis
As a halogenated pyrazine, it functions as a key intermediate for constructing more complex heterocyclic structures. Its structure allows for versatile derivatisation in synthetic pathways.
Organic Synthesis Building Block
2-Amino-5-bromopyrazine is a versatile building block for advanced organic synthesis. Its specific functional groups enable targeted chemical modifications and the creation of novel compounds.
| Molecular weight | 174.00 |
|---|---|
| Empirical formula | C4H4BrN3 |
| Assay | 97% |
| Application | Used without prior protection of the amino group in a palladium-catalyzed cross-coupling with pyridylboronic acids leading to pyrazinylpyridines.1 |
| Melting point | 113-117 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/38-43 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-5-bromopyrazine used for?
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2-Amino-5-bromopyrazine is primarily used as a building block in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions to form pyrazinylpyridines without requiring prior protection of the amino group.
What is the CAS number and formula for 2-Amino-5-bromopyrazine?
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The CAS number is 59489-71-3 and the molecular formula is C4H4BrN3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-5-bromopyrazine with an assay of 97%. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How should 2-Amino-5-bromopyrazine be handled?
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Handling requires caution due to hazards including H302 (Harmful if swallowed), H315 (Causes skin irritation), H317 (May cause an allergic skin reaction), and H318 (Causes serious eye damage). Use a dust mask type N95, eyeshields, faceshields, and gloves. Ensure adequate ventilation.
Is 2-Amino-5-bromopyrazine a controlled substance?
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The provided data does not indicate that 2-Amino-5-bromopyrazine is a controlled substance.
How is 2-Amino-5-bromopyrazine packed and shipped?
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2-Amino-5-bromopyrazine is carefully packed according to industry standards for safe transportation and export. Specific packaging details are available upon request.
How can I request a sample or quote for 2-Amino-5-bromopyrazine?
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To request a sample or quote, please contact our sales department through the website or by phone, providing your specific requirements.
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