2,5-Thiophenedicarbonyl dichloride

CAS 3857-36-1C6H2Cl2O2SChemical Synthesis

2,5-Thiophenedicarbonyl dichloride (CAS 3857-36-1) is a chemical compound with the molecular formula C6H2Cl2O2S and a molecular weight of 209.05 g/mol. This thiophene derivative functions as a crucial building block in organic synthesis. Its primary application lies in the preparation of chiral bis-oxazoline ligands, which are vital components in asymmetric catalysis for reactions such as cyclopropanations. Supplied with an assay of 97%, it is suitable for research and development purposes.

IUPAC: 2,5-Bis(chlorocarbonyl)thiophene
Synonyms: 2,5-Bis(chlorocarbonyl)thiophene

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2,5-Thiophenedicarbonyl dichloride (C6H2Cl2O2S) — chemical structure, CAS 3857-36-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC4 to C6Chemical SynthesisHeterocyclic Building BlocksThiophenes

01 /Applications

Chiral Ligand Synthesis

2,5-Thiophenedicarbonyl dichloride serves as a key precursor for synthesising chiral bis-oxazoline ligands. These ligands are essential for enantioselective catalysis, enabling the production of specific stereoisomers in chemical reactions.

Asymmetric Catalysis

The derived chiral bis-oxazoline ligands are employed in copper- and ruthenium-catalyzed asymmetric cyclopropanations. This application facilitates the stereoselective formation of cyclopropane rings, a common motif in pharmaceuticals and natural products.

Organic Synthesis Intermediate

As a difunctional thiophene derivative, it is a versatile building block in broader organic synthesis pathways. Its reactive acid chloride groups allow for diverse derivatisation and incorporation into complex molecular structures.

02 /Properties

Molecular weight	209.05
Empirical formula	C6H2Cl2O2S
Assay	97%
Boiling point	150-152 °C/11 mmHg
Storage temperature	2-8°C
Application	Building block for the synthesis of chiral bis-oxazoline ligands used in copper- and ruthenium-catalyzed asymmetric cyclopropanations.1,2
Melting point	43-47 °C

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Flash point	>110 °C / >230 °F
Transport (UN / ADR)	UN 3261 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

3857-36-1

MDL number

MFCD06654886

PubChem substance

24884613

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,5-Thiophenedicarbonyl dichloride used for?

2,5-Thiophenedicarbonyl dichloride is primarily used as a building block for the synthesis of chiral bis-oxazoline ligands, which are employed in copper- and ruthenium-catalyzed asymmetric cyclopropanations.

What is the CAS number and molecular formula for 2,5-Thiophenedicarbonyl dichloride?

The CAS number is 3857-36-1 and the molecular formula is C6H2Cl2O2S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2,5-Thiophenedicarbonyl dichloride with an assay of 97%. This is a technical grade suitable for research and chemical synthesis; TSS does not represent it as USP, BP, or EP grade.

How should 2,5-Thiophenedicarbonyl dichloride be handled safely?

2,5-Thiophenedicarbonyl dichloride is a corrosive substance (H314) causing severe skin burns and eye damage. Handle with appropriate personal protective equipment, including gloves, eye shields, and a face shield. Ensure adequate ventilation and use a respirator if necessary. Refer to the safety data sheet for full details.

Does TSS export 2,5-Thiophenedicarbonyl dichloride?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,5-Thiophenedicarbonyl dichloride.

How can I request a quote or sample for 2,5-Thiophenedicarbonyl dichloride?

To request a quote or sample, please contact our sales department through the website or by calling our customer service line. Specify the product name and CAS number for efficient processing.