2,5-Dimethylindole
2,5-Dimethylindole (CAS: 1196-79-8) is a chemical compound with the molecular formula C10H11N and a molecular weight of 145.20. This indole derivative serves as a valuable building block in organic synthesis. Its primary applications involve its use as a reactant in stereoselective syntheses, including the preparation of substituted indoles and indolines, as well as in the development of fluorene derivatives and bis-indolyldihydroxybenzoquinones.
- Synonyms
- C10H11N2,5-Dimethyl-1H-indole
Stereoselective Indole Synthesis
Utilised as a reactant in rhodium-catalyzed enantioselective coupling reactions with diazo compounds for the stereoselective preparation of substituted indoles.
Indoline Preparation
Serves as a reactant in palladium-catalyzed asymmetric hydrogenation for the stereoselective synthesis of indolines from unprotected indoles.
Fluorene Derivative Synthesis
Acts as a reactant in Friedel-Crafts reactions for the enantioselective synthesis of fluorene derivatives.
Bis-indolyldihydroxybenzoquinone Preparation
Employed as a reactant in the addition of indoles to dichlorobenzoquinone, promoted by Bronsted acid, for the synthesis of bis-indolyldihydroxybenzoquinones.
Reaction with Hydroxypyrazolines
A reactant in chemical reactions involving hydroxypyrazolines.
| Molecular weight | 145.20 |
|---|---|
| Empirical formula | C10H11N |
| Assay | 97% |
| Application | • Reactant in stereoselective preparation of substituted indoles via rhodium-catalyzed enantioselective coupling reaction of indoles with diazo compounds1• Reactant in stereoselective synthesis of indolines via palladium-catalyzed asymmetric hydrogenation of unprotected indoles2• Reactant in enantioselective synthesis of fluorene derivatives via Friedel-Crafts reactions3• Reactant in preparation of bis-indolyldihydroxybenzoquinones by addition indoles to dichlorobenzoquinone promoted by Bronsted acid4• Reactant in reaction with hydroxypyrazolines5 |
| Melting point | 112-113 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Dimethylindole used for?
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2,5-Dimethylindole (CAS: 1196-79-8) is used as a reactant in various stereoselective syntheses, including the preparation of substituted indoles, indolines, fluorene derivatives, and bis-indolyldihydroxybenzoquinones.
What are the CAS number and formula for 2,5-Dimethylindole?
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The CAS number for 2,5-Dimethylindole is 1196-79-8, and its empirical formula (Hill notation) is C10H11N.
What grade and purity does Tech Serve Solutions supply for 2,5-Dimethylindole?
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Tech Serve Solutions supplies 2,5-Dimethylindole with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,5-Dimethylindole be handled safely?
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2,5-Dimethylindole is classified with GHS symbols GHS05 and GHS07, with a signal word of 'Danger'. It causes skin irritation (H315), serious eye damage (H318), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, ensuring good ventilation, and avoid contact with eyes and skin. Precautionary statements include P261, P280, and P305 + P351 + P338.
Can I request a sample or quote for 2,5-Dimethylindole?
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Yes, you can request a sample or a quote for 2,5-Dimethylindole by contacting our sales team through the website or by calling us directly. Please specify the quantity required.
Is 2,5-Dimethylindole packed and exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,5-Dimethylindole, and can arrange for its careful packing and international shipment.
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