2,5-Dimethoxyphenylboronic acid
2,5-Dimethoxyphenylboronic acid (CAS: 107099-99-0) is an organoboron compound with the molecular formula C8H11BO4 and a molecular weight of 181.98 g/mol. This aryl boronic acid serves as a valuable building block in organic synthesis. It is particularly utilised as a reactant in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura and Negishi couplings, enabling the formation of carbon-carbon bonds in complex molecule construction.
- IUPAC
- 2,5-Dimethoxybenzeneboronic acid
- Synonyms
- (CH3O)2C6H3B(OH)22,5-Dimethoxybenzeneboronic acid
Suzuki-Miyaura Coupling Reagent
2,5-Dimethoxyphenylboronic acid is a key reactant in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed process facilitates the formation of carbon-carbon bonds by coupling the boronic acid derivative with organic halides or pseudohalides.
Negishi Coupling Participant
This compound can also participate in Negishi couplings, another powerful organometallic cross-coupling reaction. It reacts with organozinc halides in the presence of a palladium or nickel catalyst to construct new carbon-carbon bonds.
Organic Synthesis Building Block
As a disubstituted aryl boronic acid, it serves as a versatile intermediate in the synthesis of diverse organic molecules. Its specific substitution pattern makes it useful for introducing the 2,5-dimethoxyphenyl moiety into larger structures.
| Molecular weight | 181.98 |
|---|---|
| Linear formula | (CH3O)2C6H3B(OH)2 |
| Application | Reactant for:• Suzuki-Miyaura1,2,3,4 and Negishi couplings4 |
| Melting point | 95-98 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Dimethoxyphenylboronic acid used for?
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2,5-Dimethoxyphenylboronic acid is primarily used as a reactant in Suzuki-Miyaura and Negishi cross-coupling reactions for the synthesis of complex organic molecules. It functions as a versatile building block in organic synthesis.
What is the CAS number and formula for 2,5-Dimethoxyphenylboronic acid?
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The CAS number for 2,5-Dimethoxyphenylboronic acid is 107099-99-0. Its linear formula is (CH3O)2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply for 2,5-Dimethoxyphenylboronic acid?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. We provide accurate assays for our products; please refer to the specification sheet for lot-specific details. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety considerations when handling 2,5-Dimethoxyphenylboronic acid?
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According to the supplied data, appropriate personal protective equipment, including eyeshields and gloves, should be used. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3, indicating a high hazard to water.
Is 2,5-Dimethoxyphenylboronic acid a controlled substance?
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The provided data does not indicate that 2,5-Dimethoxyphenylboronic acid is a controlled substance.
How is 2,5-Dimethoxyphenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals, pharmaceutical intermediates, and laboratory reagents. Products are carefully packed according to international shipping regulations to ensure safe transit worldwide. Specific packaging details can be provided upon request.
How can I request a quote or sample of 2,5-Dimethoxyphenylboronic acid?
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To request a quote or a sample of 2,5-Dimethoxyphenylboronic acid, please contact our sales team through the website or by calling our office. Our team will be happy to assist you with your specific requirements.
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