2,4-Difluorotoluene
2,4-Difluorotoluene (CAS: 452-76-6) is a fluorinated organic compound with the molecular formula CH3C6H3F2 and a molecular weight of 128.12 g/mol. This compound serves as a valuable building block in organic synthesis. Its primary application involves its use in the synthesis of novel hydrophobic isosteres of pyrimidines and purine nucleosides, contributing to advancements in medicinal chemistry and pharmaceutical research.
- Synonyms
- CH3C6H3F2
Synthesis of Nucleoside Analogues
2,4-Difluorotoluene is instrumental in the creation of new hydrophobic isosteres for pyrimidines and purine nucleosides. These modified nucleosides can have significant implications in drug discovery and development.
Fluorinated Organic Building Block
As a versatile aryl fluorinated building block, this compound is employed in various chemical synthesis pathways. Its structure allows for the introduction of difluorotoluene moieties into complex organic molecules.
Medicinal Chemistry Research
The compound's utility extends to medicinal chemistry, where it facilitates the exploration of novel molecular structures with potential therapeutic properties. It aids in the design of compounds targeting specific biological pathways.
| Molecular weight | 128.12 |
|---|---|
| Linear formula | CH3C6H3F2 |
| Assay | 99% |
| Boiling point | 113-117 °C(lit.) |
| Density | 1.12 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.449(lit.) |
| Application | 2,4-Difluorotoluene was used in the synthesis of new hydrophobic isosteres of pyrimidines and purine nucleosides1. |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 15 °C / 59 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-29-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorotoluene used for?
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2,4-Difluorotoluene is primarily used in chemical synthesis, notably in the creation of new hydrophobic isosteres of pyrimidines and purine nucleosides, and as a versatile fluorinated organic building block.
What is the CAS number and formula for 2,4-Difluorotoluene?
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The CAS number for 2,4-Difluorotoluene is 452-76-6, and its linear formula is CH3C6H3F2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorotoluene with a purity of 99% (assay). This product is not supplied as USP, BP, or EP grade.
How should 2,4-Difluorotoluene be handled safely?
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2,4-Difluorotoluene is a flammable liquid and vapour (H225) and requires careful handling. Safety precautions include using approved personal protective equipment such as eyeshields, faceshields, appropriate gloves, and suitable respiratory protection. Store away from ignition sources in a well-ventilated area, following all safety recommendations (P210).
Is 2,4-Difluorotoluene shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,4-Difluorotoluene, which can be shipped internationally according to relevant regulations (UN 1993).
How can I request a quote or sample for 2,4-Difluorotoluene?
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To request a quote or sample for 2,4-Difluorotoluene, please contact our sales department through the website or by phone, providing your specific requirements.
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