2,4-Bis(trifluoromethyl)phenylboronic acid

CAS 153254-09-2C8H5BF6O2Chemical Synthesis

2,4-Bis(trifluoromethyl)phenylboronic acid (CAS: 153254-09-2) is a specialised organoboron compound with the molecular formula C8H5BF6O2 and a molecular weight of 257.93 g/mol. This compound serves as a key building block in organic synthesis. Its trifluoromethyl groups impart unique electronic properties, making it valuable in the preparation of diverse complex molecules, particularly in pharmaceutical research and materials science.

IUPAC: (2,4-Ditrifluoromethylphenyl)boronic acid,2,4-Bis(trifluoromethyl)benzeneboronic acid,2,4-Di(trifluoromethyl)benzeneboronic acid
Synonyms: C8H5BF6O2(2,4-Ditrifluoromethylphenyl)boronic acid2,4-Bis(trifluoromethyl)benzeneboronic acid2,4-Di(trifluoromethyl)benzeneboronic acid

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2,4-Bis(trifluoromethyl)phenylboronic acid (C8H5BF6O2) — chemical structure, CAS 153254-09-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Corticotropin-Releasing Factor 1 Receptor Antagonists

Utilised as a reactant in the synthesis of pyrrolo[2,3-d]pyrimidin-4-ones. These compounds are investigated for their potential as corticotropin-releasing factor 1 receptor antagonists.

Sodium Channel Blockers

Employed in the preparation of biaryl pyrazole carboxamides. These molecules are explored for their efficacy as sodium channel blockers, particularly for the treatment of neuropathic pain.

Modulators of Inflammation and Bone Loss

Serves as a precursor in the synthesis of biphenylketones, which are studied for their dual modulatory effects on inflammation and bone loss.

Luminescent Materials

Used in the development of blue luminescent iridium phenylpyridine complexes, indicating potential applications in materials science and optoelectronics.

02 /Properties

Molecular weight	257.93
Empirical formula	C8H5BF6O2
Application	Reactant for preparation of:• Pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor1• Biaryl pyrazole carboxamides as sodium channel blockers for treatment of neuropathic pain2• Biphenylketones as dual modulators of inflammation and bone loss3• (Biphenylyl)pyrazolecarboxamides and their voltage-gated sodium channel Nav1.7 blocking structure-activity relationship4• N-hydroxyalkyl biphenylsulfonamides as inhibitors of bone resorption5• 1,3,6,8a-tetraazaacenaphthylene derivatives and study of their activity as corticotropin-releasing factor-1 antagonists6• Blue luminescent iridium phenylpyridine complexes7
Melting point	110-117 °C

03 /Identifiers & registry

CAS number

153254-09-2

MDL number

MFCD01631349

PubChem substance

24885790

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is 2,4-Bis(trifluoromethyl)phenylboronic acid used for?

2,4-Bis(trifluoromethyl)phenylboronic acid is used as a reactant in organic synthesis for the preparation of various complex molecules, including pharmaceutical intermediates and specialised materials like luminescent complexes.

What are the CAS number and chemical formula for 2,4-Bis(trifluoromethyl)phenylboronic acid?

The CAS number is 153254-09-2, and the empirical formula is C8H5BF6O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical for research and development purposes. The specific grade and purity available may vary. Please contact us for current specifications. We do not represent this product as meeting USP/BP/EP or any other pharmacopoeia standards.

What are the safety and handling considerations for 2,4-Bis(trifluoromethyl)phenylboronic acid?

This compound is classified under WGK 2, indicating it is hazardous to water. Appropriate personal protective equipment should be worn, and it should be handled in a well-ventilated area to avoid exposure. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information.

How is 2,4-Bis(trifluoromethyl)phenylboronic acid packed, shipped, and exported?

Tech Serve Solutions expertly packs and exports fine chemicals globally, adhering to all relevant shipping and safety regulations for hazardous materials.

How can I request a sample or quote for 2,4-Bis(trifluoromethyl)phenylboronic acid?

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