2,4,5-Trifluoro-3-methoxybenzoyl chloride
2,4,5-Trifluoro-3-methoxybenzoyl chloride (CAS: 112811-66-2) is a fluorinated aryl building block. With a molecular weight of 224.56 g/mol, this compound serves as a key intermediate in organic synthesis. Its reactivity as an acid chloride makes it valuable for introducing the 2,4,5-trifluoro-3-methoxybenzoyl moiety into various molecular structures, finding utility in research and development for the creation of novel compounds.
- Synonyms
- 112811-66-2HC6F3(OCH3)COCl

Organic Synthesis Intermediate
Utilised as a reactive intermediate in complex organic syntheses, particularly in the pharmaceutical and agrochemical industries for the construction of target molecules.
Fluorinated Building Block
Serves as a valuable fluorinated building block, enabling the introduction of trifluorinated aromatic systems into organic frameworks, crucial for modulating compound properties.
Chemical Research and Development
Employed in R&D settings for the exploration of new chemical entities and the development of novel synthetic routes, leveraging its specific functional groups.
| Molecular weight | 224.56 |
|---|---|
| Linear formula | HC6F3(OCH3)COCl |
| Assay | 97% |
| Density | 1.472 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.503(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,5-Trifluoro-3-methoxybenzoyl chloride used for?
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2,4,5-Trifluoro-3-methoxybenzoyl chloride is used as a key intermediate in organic synthesis, particularly for introducing the 2,4,5-trifluoro-3-methoxybenzoyl group into other molecules during chemical research and development.
What are the CAS number and chemical formula for this product?
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The CAS number for 2,4,5-Trifluoro-3-methoxybenzoyl chloride is 112811-66-2. The linear formula is HC<sub>6</sub>F<sub>3</sub>(OCH<sub>3</sub>)COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. This is a technical or research grade chemical and is not represented as USP, BP, or EP grade.
How should 2,4,5-Trifluoro-3-methoxybenzoyl chloride be handled safely?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). It requires stringent safety precautions, including the use of full-face respirators, chemical-resistant gloves, goggles, and face shields. Appropriate respirator filters (e.g., type ABEK) should be used.
How is this chemical packed and shipped?
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This chemical is shipped as UN 1760, Class 8, Packing Group II, indicating it is a corrosive material requiring specialised handling and transportation protocols.
How can I request a sample or quote?
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To request a sample or a quotation, please contact the TSS sales department through our website or by phone, providing the product name and CAS number (112811-66-2).
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