2,4,5,6-Tetrachloropyrimidine
2,4,5,6-Tetrachloropyrimidine (CAS: 1780-40-1; C4Cl4N2) is a halogenated heterocyclic compound with a molecular weight of 217.87 g/mol. This building block is primarily utilised in organic synthesis, serving as a key intermediate for creating more complex molecular structures. Its applications include its use in Suzuki-Miyaura reactions to form substituted pyrimidines and in the synthesis of fused heterocyclic systems like benzofuropyrimidines.
- Synonyms
- 6-Tetrachloropyrimidine1780-40-1C4Cl4N2
Suzuki-Miyaura Reactions
This tetrachlorinated pyrimidine derivative is employed as a substrate in Suzuki-Miyaura cross-coupling reactions. It enables the synthesis of mono-, di-, tri-, and tetra-arylpyrimidines by forming new carbon-carbon bonds with boronic acids or esters.
Synthesis of Fused Heterocycles
2,4,5,6-Tetrachloropyrimidine is a precursor for constructing fused heterocyclic ring systems. It has been specifically used in the regioselective Suzuki coupling with boronic acid to synthesise benzofuropyrimidine derivatives.
Heterocyclic Building Block
As a functionalised pyrimidine, it serves as a versatile building block in medicinal chemistry and materials science research. The reactive chlorine atoms can be selectively substituted to introduce various functionalities.
| Molecular weight | 217.87 |
|---|---|
| Empirical formula | C4Cl4N2 |
| Assay | 97% |
| Application | 2,4,5,6-Tetrachloropyrimidine has been used in the synthesis of:• mono-, di-, tri- and tetra-arylpyrimidines via Suzuki-Miyaura reaction1• benzofuropyrimidine via regioselective Suzuki coupling with boronic acid1 |
| Melting point | 68-70 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-27-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,5,6-Tetrachloropyrimidine used for?
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2,4,5,6-Tetrachloropyrimidine (CAS: 1780-40-1) is used as a building block in organic synthesis, notably in Suzuki-Miyaura reactions to produce arylpyrimidines and in the creation of fused heterocycles such as benzofuropyrimidines.
What is the CAS number and chemical formula for 2,4,5,6-Tetrachloropyrimidine?
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The CAS number is 1780-40-1, and the empirical formula (Hill notation) is C4Cl4N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,5,6-Tetrachloropyrimidine with a minimum assay of 97%. This product is supplied for research and laboratory purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,4,5,6-Tetrachloropyrimidine be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (N95 or equivalent). Avoid inhalation of dust and contact with skin and eyes. This compound is classified as an irritant to the skin, eyes, and respiratory tract (H315, H319, H335).
Does TSS export 2,4,5,6-Tetrachloropyrimidine?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,4,5,6-Tetrachloropyrimidine.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales team through the website or by phone, providing the product name and CAS number (1780-40-1).
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