2-((3-Trifluoromethyl)phenyl)histamine dimaleate
2-((3-Trifluoromethyl)phenyl)histamine dimaleate (CAS: 162049-83-4) is a potent histamine H1 receptor agonist with the molecular formula C20H20F3N3O8 and a molecular weight of 487.38 g/mol. This off-white powder is supplied with a purity of ≥98% by HPLC. It is primarily utilised in biochemical research, particularly in studies involving cell signalling, neurotransmission, and the investigation of G-protein coupled receptors (GPCRs).
- IUPAC
- (2-[2-(3-Trifluoromethyl)phenyl)-1H-imidazol-4-yl]ethanamine dimaleate,Compound 39
Goblet Cell Secretion Studies
This compound has been employed in research to investigate the mechanisms underlying goblet cell secretion in biological models, as documented in scientific literature.
H1 Receptor Function Research
It serves as a tool for studying the role of the histamine H1 receptor in regulating pathways such as COX-2 and prostanoid homeostasis within human vascular endothelial cells.
Neuroscience and Cell Signaling
As a bioactive small molecule, it aids in exploring cell signalling pathways and neurotransmission processes within the field of neuroscience.
| Molecular weight | 487.38 |
|---|---|
| Empirical formula | C20H20F3N3O8 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | off-white |
| Solubility | H2O: ~20 mg/mL |
| Storage temperature | 2-8°C |
| Application | 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been used to study the induction of goblet cell secretion in rats3. 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has also been used to study the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells4. |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-37/38-41 |
| Safety statements (S) | 26-39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-((3-Trifluoromethyl)phenyl)histamine dimaleate used for?
+
2-((3-Trifluoromethyl)phenyl)histamine dimaleate is used in biochemical research, including studies on goblet cell secretion, H1 receptor function, cell signalling, and neurotransmission.
What is the CAS number and molecular formula for 2-((3-Trifluoromethyl)phenyl)histamine dimaleate?
+
The CAS number is 162049-83-4 and the molecular formula is C20H20F3N3O8.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2-((3-Trifluoromethyl)phenyl)histamine dimaleate with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should 2-((3-Trifluoromethyl)phenyl)histamine dimaleate be handled safely?
+
This compound is a Danger substance (GHS05, GHS06) and is harmful if swallowed (H301), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate PPE, including eyeshields, face shields, gloves, and a P2 respirator, is essential. Handle only in a well-ventilated area. In case of exposure, seek immediate medical advice.
How is 2-((3-Trifluoromethyl)phenyl)histamine dimaleate shipped?
+
This product is shipped as a UN 2811, Class 6.1, Packing Group III substance. It requires careful handling and appropriate documentation for international export.
How can I request a sample or quote for this chemical?
+
To request a sample or a quote, please contact our sales team via the website or by phone, providing the product name and CAS number (162049-83-4).
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis