2,3,6-Trifluorophenylboronic acid
2,3,6-Trifluorophenylboronic acid (CAS: 247564-71-2) is an organoboron compound with the linear formula C6H2F3B(OH)2 and a molecular weight of 175.90 g/mol. It is a key building block and reactant in organic synthesis. Its primary applications lie in palladium-catalyzed cross-coupling reactions, notably Suzuki-Miyaura couplings, for the construction of complex organic molecules, including pharmaceutical intermediates.
- Synonyms
- 247564-71-2C6H2F3B(OH)2
Suzuki Coupling Reactions
Utilised as a crucial reactant in palladium-catalyzed Suzuki-Miyaura coupling reactions for the formation of carbon-carbon bonds. This enables the synthesis of diverse biaryl compounds and complex organic frameworks.
Synthesis of Pharmaceutical Intermediates
Employed in the synthesis of advanced intermediates, such as a C-6 hydroxy tricyclic sulfone, which acts as a gamma-secretase inhibitor. This highlights its role in drug discovery and development pathways.
Organometallic Chemistry
Serves as a versatile organometallic reagent in various synthetic transformations, contributing to the development of novel chemical entities in research and development settings.
| Molecular weight | 175.90 |
|---|---|
| Linear formula | C6H2F3B(OH)2 |
| Application | Reactant for:• Synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor via Suzuki coupling reaction1• Palladium catalyzed Suzuki-Miyaura coupling reactions2,3 |
| Melting point | 127-132 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3,6-Trifluorophenylboronic acid used for?
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2,3,6-Trifluorophenylboronic acid is primarily used as a reactant in palladium-catalyzed Suzuki-Miyaura coupling reactions for synthesizing complex organic molecules, including intermediates for pharmaceuticals.
What is the CAS number and formula for 2,3,6-Trifluorophenylboronic acid?
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The CAS number is 247564-71-2 and the linear formula is C6H2F3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research-grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia standard unless explicitly stated in the product specifications.
What are the safety and handling precautions for 2,3,6-Trifluorophenylboronic acid?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please consult the full Safety Data Sheet (SDS) for detailed hazard information.
Is 2,3,6-Trifluorophenylboronic acid a controlled substance?
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The provided data does not indicate that 2,3,6-Trifluorophenylboronic acid is a controlled substance.
How is 2,3,6-Trifluorophenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping and customs regulations. Packaging is designed to ensure product integrity and safety during transit.
How can I request a sample or quote for 2,3,6-Trifluorophenylboronic acid?
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You can request a sample or a detailed quote by contacting our sales team through the website or by calling us directly. Please reference the product name and CAS number.
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