2,3,5-Trifluorophenylboronic acid
2,3,5-Trifluorophenylboronic acid (CAS: 247564-73-4) is a specialised organoboronic acid with the linear formula F<sub>3</sub>C<sub>6</sub>H<sub>2</sub>B(OH)<sub>2</sub> and a molecular weight of 175.90 g/mol. It serves as a key reactant in organic synthesis, particularly for creating novel biologically active compounds. Its trifluorophenyl moiety offers unique electronic properties, making it valuable in medicinal chemistry research and the development of pharmaceuticals.
- Synonyms
- 247564-73-4F3C6H2B(OH)2
Synthesis of GPCR Agonists
This boronic acid is utilised as a reactant in the synthesis of pyrazole-based compounds, specifically designed to act as agonists for the human orphan G protein-coupled receptor GPR109a.
Development of Niacin Receptor Modulators
It is involved in the preparation of bicyclic pyrazole carboxylic acid derivatives, which function as agonists targeting the niacin receptor.
Creation of Heterocyclic Compounds
The compound facilitates the synthesis of complex heterocyclic structures such as 5-alkyl and 5-aryl-pyrazole-tetrazoles, also investigated for their GPR109a agonist activity.
| Molecular weight | 175.90 |
|---|---|
| Linear formula | F3C6H2B(OH)2 |
| Assay | ≥95% |
| Application | Reactant involved in the synthesis of biologically active compounds:• Pyrazole-acids to be used as agonists of human orphan GPCR GPR109a1• Bicyclic pyrazole carboxylic acid derivatives as a niacin receptor agonist2• 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of human orphan GPCR GPR109a3 |
| Melting point | 221 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3,5-Trifluorophenylboronic acid used for?
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2,3,5-Trifluorophenylboronic acid is used as a reactant in the synthesis of biologically active compounds, including pyrazole derivatives investigated as agonists for the human orphan GPCR GPR109a and niacin receptor modulators.
What are the CAS number and formula for 2,3,5-Trifluorophenylboronic acid?
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The CAS number for 2,3,5-Trifluorophenylboronic acid is 247564-73-4 and its linear formula is F3C6H2B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,3,5-Trifluorophenylboronic acid with an assay of ≥95%. We do not represent this product as USP/BP/EP grade; it is supplied for research and laboratory use.
What are the safety considerations when handling 2,3,5-Trifluorophenylboronic acid?
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Handling 2,3,5-Trifluorophenylboronic acid requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. The compound is classified with WGK Germany 3.
How is 2,3,5-Trifluorophenylboronic acid packed and shipped?
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Tech Serve Solutions expertly packs and exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, adhering to all necessary regulations for safe and secure transit.
How can I request a sample or quote for 2,3,5-Trifluorophenylboronic acid?
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To request a sample or a quote for 2,3,5-Trifluorophenylboronic acid, please contact our sales team through the website or by phone. We are dedicated to serving your chemical needs.
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