2,3,5,6-Tetramethylphenylboronic acid
2,3,5,6-Tetramethylphenylboronic acid (CAS: 197223-36-2) is an organoboronic acid with the molecular formula C₆H(CH₃)₄B(OH)₂ and a molecular weight of 178.04 g/mol. It is a substituted aryl boronic acid derivative. This compound serves as a valuable building block in organic synthesis, particularly in cross-coupling reactions, facilitating the formation of carbon-carbon bonds in complex molecules. It is primarily used in chemical research and development.
- Synonyms
- 6-Tetramethylphenylboronic acid197223-36-2C6H(CH3)4B(OH)2

Organic Synthesis
Utilised as a coupling partner in various cross-coupling reactions, such as Suzuki-Miyaura couplings. This enables the efficient construction of substituted aromatic compounds and complex organic architectures.
Pharmaceutical Intermediates
Serves as a key intermediate in the synthesis of potential drug candidates and active pharmaceutical ingredients (APIs). Its structure allows for the introduction of specific tetramethylphenyl moieties into target molecules.
Materials Science Research
Explored for its use in the development of novel organic materials, including those with optoelectronic properties, due to the unique electronic and steric characteristics of the tetramethylphenyl group.
| Molecular weight | 178.04 |
|---|---|
| Linear formula | C6H(CH3)4B(OH)2 |
| Melting point | 145-148 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3,5,6-Tetramethylphenylboronic acid used for?
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2,3,5,6-Tetramethylphenylboronic acid is primarily used as a reagent in organic synthesis, particularly for cross-coupling reactions like the Suzuki-Miyaura coupling. It acts as a building block for creating complex organic molecules, including potential pharmaceutical intermediates and materials for scientific research.
What is the CAS number and chemical formula for 2,3,5,6-Tetramethylphenylboronic acid?
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The CAS number for 2,3,5,6-Tetramethylphenylboronic acid is 197223-36-2, and its linear formula is C₆H(CH₃)₄B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, EP, BP, or any pharmacopoeia grade.
How should 2,3,5,6-Tetramethylphenylboronic acid be handled and stored?
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This compound requires appropriate personal protective equipment, including eyeshields and gloves. Respiratory protection, such as a type N95 (US) or type P1 (EN143) respirator filter, is recommended. Store in a well-ventilated area according to standard chemical storage practices, away from incompatible materials.
Is 2,3,5,6-Tetramethylphenylboronic acid a controlled substance?
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Based on the provided data, there is no indication that 2,3,5,6-Tetramethylphenylboronic acid is a controlled substance.
How is 2,3,5,6-Tetramethylphenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions ensures that all products are packed, shipped, and exported in compliance with relevant regulations. Details regarding specific packaging for this chemical can be provided upon request.
How can I request a sample or quote for 2,3,5,6-Tetramethylphenylboronic acid?
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To request a sample or a quotation, please contact our sales department through the provided channels on our website, specifying the product name and CAS number (197223-36-2).
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