2,2,2-Trichloroethyl chloroformate
2,2,2-Trichloroethyl chloroformate (CAS: 17341-93-4), with the molecular formula ClCOOCH₂CCl₃ and a molecular weight of 211.86 g/mol, is a key organic building block. It serves as a derivatizing reagent in analytical chemistry, a starting material in organic synthesis, and a protecting group reagent for amines and alcohols. Its reactive nature demands careful handling in laboratory and industrial settings.
- IUPAC
- 2,2,2-Trichloroethoxycarbonyl chloride
- Synonyms
- 17341-93-4ClCOOCH2CCl32,2,2-Trichloroethoxycarbonyl chloride
Derivatizing Reagent in Chromatography
Utilised in gas chromatography/mass spectrometry for the determination of amphetamine-related drugs and ephedrines in biological samples like plasma, urine, and hair.
Organic Synthesis
Acts as a starting reagent in the synthesis of complex organic molecules, such as 6-nor-9,10-dihydrolysergic acid methyl ester.
N-Demethylation
Employed as a reagent for the removal of N-methyl groups, exemplified by its use in the demethylation of dextromethorphan.
Protecting Group Chemistry
Functions as an effective reagent for introducing protecting groups onto amines and alcohols, facilitating selective chemical transformations.
| Molecular weight | 211.86 |
|---|---|
| Linear formula | ClCOOCH2CCl3 |
| Assay | ≥98.0% (NT) |
| Boiling point | 171-172 °C(lit.) |
| Density | 1.539 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.471(lit.)n20/D 1.471 |
| Vapour pressure | 0.06 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | 2,2,2-Trichloroethyl chloroformate was used as:• derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples1• starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)2• reagent during N-demethylation of dextromethorphan3• protecting group reagent for amines and alcohols 4,5 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3277 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,2-Trichloroethyl chloroformate used for?
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2,2,2-Trichloroethyl chloroformate is used as a derivatizing reagent in GC/MS analysis, a starting material in organic synthesis, for N-demethylation reactions, and as a protecting group reagent for amines and alcohols.
What is the CAS number and formula for 2,2,2-Trichloroethyl chloroformate?
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The CAS number is 17341-93-4, and its linear formula is ClCOOCH₂CCl₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2,2-Trichloroethyl chloroformate with an assay of ≥98.0% (NT). This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,2,2-Trichloroethyl chloroformate be handled safely?
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2,2,2-Trichloroethyl chloroformate is a danger due to its corrosive and toxic nature (H314, H331). Appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection, must be used. Handle in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for detailed handling procedures.
Is 2,2,2-Trichloroethyl chloroformate exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,2,2-Trichloroethyl chloroformate.
How can I request a sample or quote for 2,2,2-Trichloroethyl chloroformate?
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To request a sample or a quote for 2,2,2-Trichloroethyl chloroformate, please contact our sales team through the website or by phone.
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