(1S)-(+)-Menthyl chloroformate
(1S)-(+)-Menthyl chloroformate (CAS 7635-54-3) is a chiral chloroformate with the formula C11H19ClO2 and a molecular weight of 218.72 g/mol. This compound serves as a valuable chiral auxiliary in asymmetric synthesis, particularly for creating quaternary carbon centres. Its optical activity and defined stereochemistry make it a key reagent in stereoselective organic transformations, facilitating precise molecular construction.
Asymmetric Synthesis
(1S)-(+)-Menthyl chloroformate is employed as a chiral auxiliary to induce stereoselectivity in the formation of new chiral centres. It is particularly useful in the synthesis of molecules containing quaternary carbon atoms, a challenging motif in organic chemistry.
Chiral Resolution
This compound can be used in methods for resolving racemic mixtures. By forming diastereomeric derivatives with a racemic compound, separation and subsequent recovery of enantiomerically pure substances can be achieved.
Derivatization Reagent
It functions as a derivatization reagent in analytical chemistry, especially for chromatography like HPLC. Derivatization can improve the detectability or separability of analytes, particularly for chiral compounds.
| Molecular weight | 218.72 |
|---|---|
| Empirical formula | C11H19ClO2 |
| Boiling point | 108-109 °C/11 mmHg(lit.) |
| Density | 1.031 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.458(lit.) |
| Optical activity | [α]20/D +83°, c = 1 in chloroform |
| Optical purity | ee: 97% (GLC) |
| Storage temperature | 2-8°C |
| Application | Chiral auxiliary in the asymmetric synthesis of quaternary carbon centers.1 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 70 °C / 158 °F |
| Transport (UN / ADR) | UN 3277 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S)-(+)-Menthyl chloroformate used for?
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(1S)-(+)-Menthyl chloroformate is primarily used as a chiral auxiliary in asymmetric synthesis, especially for the formation of quaternary carbon centres, and as a derivatization reagent for analytical purposes.
What are the CAS number and formula for (1S)-(+)-Menthyl chloroformate?
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The CAS number is 7635-54-3 and the chemical formula is C11H19ClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1S)-(+)-Menthyl chloroformate with a specified optical purity of ee: 97% (GLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should (1S)-(+)-Menthyl chloroformate be handled safely?
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(1S)-(+)-Menthyl chloroformate is classified as Danger (GHS05, GHS06) and causes severe skin burns and eye damage (H314) and is toxic if inhaled (H331). Handling requires full protective equipment including face shields, gloves, goggles, and appropriate respirators. Always consult the Safety Data Sheet (SDS) before use.
Is (1S)-(+)-Menthyl chloroformate a controlled substance?
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The provided data does not indicate that (1S)-(+)-Menthyl chloroformate is a controlled substance.
How is (1S)-(+)-Menthyl chloroformate packed and shipped?
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Tech Serve Solutions professionally packs and exports chemicals globally, adhering to all relevant transport regulations for hazardous materials. Specific packaging details will be provided upon order confirmation.
How can I request a quote or sample for (1S)-(+)-Menthyl chloroformate?
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To request a quote or sample of (1S)-(+)-Menthyl chloroformate, please contact our sales department through the website or by phone, providing your details and the quantity required.
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