(1S,2S)-trans-N-Boc-2-aminocyclopentanol
(1S,2S)-trans-N-Boc-2-aminocyclopentanol (CAS 145106-43-0) is a chiral organic building block with the molecular formula C10H19NO3. This compound is primarily utilized as a reactant in asymmetric synthesis, particularly for creating constrained analogues of S-adenosyl-L-homocysteine. Its specific stereochemistry makes it valuable in stereoselective chemical transformations for research and development purposes.
- IUPAC
- ((1S,2S)-2-Hydroxycyclopentyl)carbamic acid tert-butyl ester,tert-Butyl N-((2S,1S)-2-hydroxycyclopentyl)carbamate
- Synonyms
- ((1S,2S)-2-Hydroxycyclopentyl)carbamic acid tert-butyl estertert-Butyl N-((2S,1S)-2-hydroxycyclopentyl)carbamate
Asymmetric Synthesis
Serves as a crucial chiral building block in asymmetric synthesis, enabling the stereoselective construction of complex molecules. It is employed in the synthesis of constrained analogues of S-adenosyl-L-homocysteine (SAH).
DNA Methyltransferase Inhibitors
Acts as a reactant in the synthesis of DNA methyltransferase inhibitors. The stereoselective transformations include thioesterification, thioetherification, hydrolysis, heterocyclization, and amination, leading to biologically relevant compounds.
Organic Building Block
Provides a defined stereochemical structure for incorporation into larger organic molecules. Its cyclopentanol core with a protected amine functional group offers versatile synthetic possibilities in medicinal chemistry and materials science.
| Molecular weight | 201.26 |
|---|---|
| Empirical formula | C10H19NO3 |
| Assay | ≥98.5% (GC)99% |
| Optical purity | enantiomeric ratio: ≥95:5% |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors via stereoselective thioesterification, thioetherification, hydrolysis, heterocyclization and amination1 |
Hazard statements
- H302Harmful if swallowed
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-50 |
| Safety statements (S) | 61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,2S)-trans-N-Boc-2-aminocyclopentanol used for?
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(1S,2S)-trans-N-Boc-2-aminocyclopentanol is used as a reactant in asymmetric synthesis, notably for preparing constrained analogues of S-adenosyl-L-homocysteine (SAH) and developing DNA methyltransferase inhibitors.
What is the CAS number and chemical formula for (1S,2S)-trans-N-Boc-2-aminocyclopentanol?
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The CAS number is 145106-43-0, and the empirical formula is C10H19NO3.
What grade and purity does Tech Serve Solutions supply for (1S,2S)-trans-N-Boc-2-aminocyclopentanol?
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Tech Serve Solutions supplies (1S,2S)-trans-N-Boc-2-aminocyclopentanol with an assay of ≥98.5% (GC) and 99% purity. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for (1S,2S)-trans-N-Boc-2-aminocyclopentanol?
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This compound is a Warning substance with hazards H302 (Harmful if swallowed) and H400 (Very toxic to aquatic life). Recommended personal protective equipment includes a dust mask (N95 type), eyeshields, and gloves. Handle with care to avoid ingestion and release into the environment.
How is (1S,2S)-trans-N-Boc-2-aminocyclopentanol packed and shipped?
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This product is packed and shipped according to UN 3077, Environmentally hazardous substance, solid, n.o.s. (contains (1S,2S)-trans-N-Boc-2-aminocyclopentanol), 9, III, with specific GHS hazard symbols (GHS07, GHS09) and precautionary statements (P273).
How can I request a quote or sample of (1S,2S)-trans-N-Boc-2-aminocyclopentanol?
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To request a quote or sample of (1S,2S)-trans-N-Boc-2-aminocyclopentanol, please contact our sales department via the website or by phone.
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