1H-Indole-5-carboxamide
1H-Indole-5-carboxamide (CAS: 1670-87-7; Formula: C9H8N2O) is a heterocyclic organic compound with a molecular weight of 160.17 g/mol. This building block is primarily utilised in chemical synthesis for the preparation of various biologically active molecules. Its applications span the development of potential therapeutic agents, including enzyme inhibitors and receptor modulators, highlighting its role in medicinal chemistry research.
- IUPAC
- 5-(Aminocarbonyl)-1H-indole,5-Carbamoylindole,5-Carboxamidoindole
- Synonyms
- 5-(Aminocarbonyl)-1H-indole5-Carbamoylindole5-Carboxamidoindole
Preparation of Enzyme Inhibitors
Serves as a key reactant in the synthesis of potential fructose bisphosphatase inhibitors, contributing to the development of novel therapeutic strategies.
Synthesis of Kinase Inhibitors
Used in the preparation of (indolylamino)thienopyridine-carbonitriles via substitution and Suzuki cross-coupling reactions, targeting protein kinase Cθ.
Development of Receptor Modulators
Acts as a precursor for 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indoles, which are investigated for their binding affinity to serotonin receptors.
| Molecular weight | 160.17 |
|---|---|
| Empirical formula | C9H8N2O |
| Assay | 97% |
| Solubility | DMSO: ~18 mg/mLH2O: <2 mg/mL |
| Storage temperature | 2-8°C |
| Application | • Used for preparation of potential fructose bisphosphatase inhibitors1• Reactant for preparation of (indolylamino)thienopyridine-carbonitriles using substitution and Suzuki cross-coupling as potential protein kinase Cθ inhibitors2• Reactant for preparation of 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indoles as serotonin receptor binding agents3 |
| Melting point | 159-163 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1H-Indole-5-carboxamide used for?
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1H-Indole-5-carboxamide is used as a building block in chemical synthesis, particularly for preparing potential enzyme inhibitors and receptor modulators.
What is the CAS number and formula for 1H-Indole-5-carboxamide?
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The CAS number is 1670-87-7, and the empirical formula (Hill notation) is C9H8N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1H-Indole-5-carboxamide with a minimum assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with 1H-Indole-5-carboxamide?
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1H-Indole-5-carboxamide is classified with GHS07 warning. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask, eyeshields, and gloves, should be used.
How is 1H-Indole-5-carboxamide typically stored and handled?
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It is recommended to store 1H-Indole-5-carboxamide at 2-8°C. Handle with care to avoid dust formation and inhalation, and ensure good ventilation.
Does TSS export 1H-Indole-5-carboxamide?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1H-Indole-5-carboxamide.
How can I request a quote or sample?
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To request a quote or a sample of 1H-Indole-5-carboxamide, please contact our sales team through the website or by phone.
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