12-Crown-4
12-Crown-4 (CAS 294-93-9), empirical formula C8H16O4 and molecular weight 176.21 g/mol, is a cyclic polyether. It is recognised for its ability to selectively complex alkali metal cations, particularly lithium. This property makes it valuable in various chemical synthesis applications and as a phase transfer catalyst. Available from Tech Serve Solutions at 98% purity, it serves as a key reagent in research and industrial chemistry.
- IUPAC
- 1,4,7,10-Tetraoxacyclododecane
- Synonyms
- 1,4,7,10-Tetraoxacyclododecane
Ion Complexation
12-Crown-4 demonstrates strong selectivity for smaller alkali metal cations, notably Li+. This characteristic is exploited in analytical chemistry for ion sensing and separation techniques.
Phase Transfer Catalysis
As a crown ether, 12-Crown-4 can solubilise inorganic salts in organic solvents by complexing the cation. This facilitates reactions between immiscible phases, enhancing reaction rates and yields in organic synthesis.
Chemical Synthesis Reagent
It is employed in various organic synthesis pathways where the controlled complexation of cations is required. Its application aids in promoting specific reaction mechanisms and improving product selectivity.
| Molecular weight | 176.21 |
|---|---|
| Empirical formula | C8H16O4 |
| Assay | 98% |
| Boiling point | 61-70 °C/0.5 mmHg(lit.) |
| Density | 1.089 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
| Melting point | 16 °C(lit.) |
Hazard statements
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P284Wear respiratory protection
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 12-Crown-4 used for?
+
12-Crown-4 is primarily used for ion complexation, particularly of lithium ions, and as a phase transfer catalyst in chemical synthesis.
What are the CAS number and formula for 12-Crown-4?
+
The CAS number for 12-Crown-4 is 294-93-9, and its empirical formula is C8H16O4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 12-Crown-4 with an assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 12-Crown-4 be handled safely?
+
12-Crown-4 is classified as acutely toxic if inhaled (H330) and requires stringent handling precautions. Use only in a well-ventilated area or under a fume hood, and wear appropriate personal protective equipment, including a full-face respirator and chemical-resistant gloves. Refer to the Safety Data Sheet for detailed guidance.
How is 12-Crown-4 packed and shipped?
+
12-Crown-4 is packed and shipped in compliance with regulations for hazardous materials, including UN 2810 classification (Toxic solid, organic, n.o.s.). Contact us for specific export and shipping information.
How can I request a sample or quote for 12-Crown-4?
+
To request a sample or a quote for 12-Crown-4, please contact our sales department via the website or by phone, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis