10-Hydroxywarfarin
10-Hydroxywarfarin (CAS: 83219-99-2), with the empirical formula C19H16O5 and a molecular weight of 324.33 g/mol, is a significant compound within drug metabolism research. It is primarily utilised for stereo-specific metabolic studies and for investigating its inhibitory effects on cytochrome P450 enzymes, particularly CYP2C9. This compound serves as a valuable tool for researchers studying xenobiotic metabolism and drug interactions.
- IUPAC
- 4-Dihydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
Stereo-specific Metabolic Studies
10-Hydroxywarfarin is employed in research to understand the stereoselective pathways of warfarin metabolism in biological systems. This aids in elucidating how different enantiomers are processed and their subsequent pharmacological effects.
CYP2C9 Inhibition Studies
This compound has been utilised to investigate its inhibitory potential against the cytochrome P450 enzyme CYP2C9. Such studies are crucial for understanding drug-drug interactions and predicting the metabolic fate of co-administered medications.
Drug and Xenobiotic Metabolism Research
As a metabolite or analogue of warfarin, 10-Hydroxywarfarin is used in broader research concerning drug and xenobiotic metabolism. It helps in mapping metabolic pathways and understanding enzyme kinetics involved in detoxification processes.
| Molecular weight | 324.33 |
|---|---|
| Empirical formula | C19H16O5 |
| Colour | colorless |
| Solubility | DMSO: solublemethanol: soluble |
| Storage temperature | 2-8°C |
| Application | 10-Hydroxywarfarin has been used for stereo-specific metabolic studies1. 10-Hydroxywarfarin has also been used to study its inhibitory effects on CYP2C92. |
| Melting point | 183-185 °C |
Hazard statements
- H300Fatal if swallowed
- H318Causes serious eye damage
Precautionary statements
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-41 |
| Safety statements (S) | 26-39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 10-Hydroxywarfarin used for?
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10-Hydroxywarfarin is used for stereo-specific metabolic studies and to investigate its inhibitory effects on CYP2C9.
What is the CAS number and molecular formula for 10-Hydroxywarfarin?
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The CAS number for 10-Hydroxywarfarin is 83219-99-2 and its molecular formula is C19H16O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 10-Hydroxywarfarin with a purity of >=98%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
What are the primary safety concerns when handling 10-Hydroxywarfarin?
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10-Hydroxywarfarin presents significant hazards, indicated by Danger signal word and H300 (Fatal if swallowed) and H318 (Causes serious eye damage) hazard statements. Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, is mandatory. Handle with extreme caution in a well-ventilated area.
How is 10-Hydroxywarfarin packed and shipped?
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10-Hydroxywarfarin is shipped in compliance with UN 2811, Hazard Class 6.1, Packing Group III regulations. Specific packaging details can be provided upon request to ensure safe transport and export.
How can I request a sample or quote for 10-Hydroxywarfarin?
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To request a sample or a quotation for 10-Hydroxywarfarin, please contact our sales department via the website or email, specifying the required quantity and your shipping details.
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