1-[(Trimethylsilyl)methyl]benzotriazole
1-[(Trimethylsilyl)methyl]benzotriazole (CAS: 122296-00-8, Formula: C10H15N3Si, MW: 205.33) is a specialised organic compound supplied by Tech Serve Solutions. This reagent is primarily utilised in organic synthesis for C-C bond formation, serving as a one-carbon synthon for homologation reactions. Its applications extend to the preparation of specific complex molecules, including inhibitors for protein interactions.
![1-[(Trimethylsilyl)methyl]benzotriazole (C10H15N3Si) — chemical structure, CAS 122296-00-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F122296-00-8.png&w=3840&q=75)
Alkylation Reactions
1-[(Trimethylsilyl)methyl]benzotriazole functions as a reactant in alkylation reactions, facilitating the introduction of alkyl groups into organic molecules. This is a fundamental transformation in organic synthesis.
Preparation of Inhibitors
This compound is employed in the synthesis of specific inhibitors, such as those targeting the p53-MDM2 complex formation. Such molecules are of interest in pharmaceutical research.
One-Carbon Homologation
As a one-carbon synthon, 1-[(Trimethylsilyl)methyl]benzotriazole is used for the one-carbon homologation of carboxylic acids, effectively extending carbon chains by one atom.
| Molecular weight | 205.33 |
|---|---|
| Empirical formula | C10H15N3Si |
| Assay | 99% |
| Application | New Benzotriazole ReagentsReactant for:• Alkylation reactions1• Preparation of inhibitor of p53-MDM2 complex formation2• Used as a one-carbon synthon for one-carbon homologation of carboxylic acids3 |
| Melting point | 56-60 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-[(Trimethylsilyl)methyl]benzotriazole used for?
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1-[(Trimethylsilyl)methyl]benzotriazole is used in organic synthesis for C-C bond formation, as a one-carbon synthon for homologating carboxylic acids, and in the preparation of inhibitors such as those for p53-MDM2 complex formation.
What is the CAS number and formula for 1-[(Trimethylsilyl)methyl]benzotriazole?
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The CAS number is 122296-00-8 and the empirical formula (Hill notation) is C10H15N3Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-[(Trimethylsilyl)methyl]benzotriazole with a minimum assay of 99%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
How should 1-[(Trimethylsilyl)methyl]benzotriazole be handled safely?
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1-[(Trimethylsilyl)methyl]benzotriazole is a Warning substance, classified with H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust. Ensure prompt eye washing and seek medical attention if ingested or inhaled.
Is 1-[(Trimethylsilyl)methyl]benzotriazole a controlled substance?
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The provided data does not indicate that 1-[(Trimethylsilyl)methyl]benzotriazole is a controlled substance.
How is 1-[(Trimethylsilyl)methyl]benzotriazole packed and exported?
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1-[(Trimethylsilyl)methyl]benzotriazole is carefully packaged to ensure stability and safety during transport. As a global supplier, Tech Serve Solutions handles all necessary export documentation and logistics for international shipment.
How can I request a quote or sample of 1-[(Trimethylsilyl)methyl]benzotriazole?
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To request a quote or a sample of 1-[(Trimethylsilyl)methyl]benzotriazole, please contact our sales team through the TSS website or by phone, providing your specific requirements.
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