1-Propynylmagnesium bromide solution
1-Propynylmagnesium bromide solution (CAS: 16466-97-0, CH₃C≡CMgBr) is an organometallic reagent supplied by Tech Serve Solutions. This solution, typically at 0.5 M in THF, serves as a valuable building block in organic synthesis. It is primarily utilised for the introduction of the propynyl group in complex molecule construction, contributing to the synthesis of advanced intermediates and fine chemicals.
Synthesis of Tetrahydronaphthalenes
Used in the preparation of hydroxy enynes. These intermediates undergo subsequent gold(I)-catalyzed benzannulation reactions to yield tetrahydronaphthalene derivatives, showcasing its utility in constructing complex polycyclic frameworks.
Alkynylation Reactions
As a Grignard reagent, it effectively adds the propynyl moiety to electrophilic substrates. This is crucial for creating carbon-carbon bonds and extending carbon chains in the synthesis of organic molecules.
Organometallic Chemistry
Serves as a key organometallic reagent for various transformations in synthetic organic chemistry. Its reactivity profile is essential for researchers developing novel synthetic methodologies.
| Molecular weight | 143.26 |
|---|---|
| Linear formula | CH3C≡CMgBr |
| Boiling point | 65-67 °C |
| Density | 0.941 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
| Application | Preparation of hydroxy enynes which underwent gold(I)-catalyzed benzannulation leading to tetrahydronaphthalenes.1 |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -1 °C / 30.2 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Propynylmagnesium bromide solution used for?
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1-Propynylmagnesium bromide solution is used in organic synthesis, notably for preparing hydroxy enynes which can be converted into tetrahydronaphthalenes via gold(I)-catalyzed benzannulation. It also functions as a general alkynylating agent in organometallic chemistry.
What is the CAS number and formula for 1-Propynylmagnesium bromide solution?
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The CAS number is 16466-97-0, and its linear formula is CH₃C≡CMgBr.
What grade and purity does Tech Serve Solutions supply for 1-Propynylmagnesium bromide solution?
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Tech Serve Solutions supplies 1-Propynylmagnesium bromide solution at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade. For specific purity requirements, please contact our sales team.
How should 1-Propynylmagnesium bromide solution be handled and stored?
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This product is highly flammable, reacts violently with water, and can cause severe skin burns and eye damage. It may also cause respiratory irritation. Handle under an inert atmosphere, away from heat and ignition sources, and wear appropriate personal protective equipment including gloves, goggles, and a respirator. Store at 2-8°C.
How is 1-Propynylmagnesium bromide solution shipped?
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1-Propynylmagnesium bromide solution is shipped in compliance with UN 3399, hazard class 4.3 (Dangerous when wet), packing group I, due to its reactivity with water and flammability. We are experienced global exporters of hazardous materials.
How can I request a sample or quote for 1-Propynylmagnesium bromide solution?
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To request a sample or a quotation, please contact our dedicated sales team through the contact details provided on our website. Our team will be pleased to assist you with your inquiry.
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