1-Methyl-3-indoleacetic acid
1-Methyl-3-indoleacetic acid (CAS 1912-48-7), with the molecular formula C11H11NO2 and a molecular weight of 189.21 g/mol, is a valuable heterocyclic building block. It serves as a key reactant in various stereoselective syntheses. Its applications include the preparation of chiral carboxylic acids, protein kinase inhibitors, and antifungal agents, making it a significant compound in organic synthesis and medicinal chemistry research.
- IUPAC
- 2-(N-Methylindole-3-yl)acetic acid,NSC 78007
- Synonyms
- 2-(N-Methylindole-3-yl)acetic acidNSC 78007
Enantioselective Synthesis
Utilised as a reactant for the enantioselective preparation of alpha-aryl alkylcarboxylic acids, contributing to the synthesis of chiral molecules.
Medicinal Chemistry
A key reactant in the preparation of compounds like methylindolylpyridinylmethylpiperidinylindolylpyrroledione, used for protein kinase C imaging, and also for (indolyl)pyrrol-2-ones as potential antiangiogenic and protein kinase inhibitors.
Stereoselective Preparation of Lactones
Serves as a reactant for the stereoselective synthesis of delta-lactones through Michael addition/lactonization pathways with unsaturated carboxylates.
Antifungal Agent Synthesis
Employed in the synthesis of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues, which exhibit antifungal properties.
Synthesis of Vindoline Analogues
Acts as a reactant in the stereoselective preparation of vindorosine, vindoline, and related analogues.
| Molecular weight | 189.21 |
|---|---|
| Empirical formula | C11H11NO2 |
| Assay | 98% |
| Application | • Reactant for enantioselective preparation of α-aryl alkylcarboxylic acids1• Reactant for preparation of PKC inhibitor methylindolylpyridinylmethylpiperidinylindolylpyrroledione for protein kinase C imaging2• Reactant for stereoselective preparation of δ-lactones via Michael addition/lactonization with unsaturated carboxylates3• Reactant for stereoselective preparation of vindorosine, vindoline, and analogs4• Reactant for preparation of (indolyl)pyrrol-2-ones as VEGF-R inhibitors, antiangiogenic agents, and protein kinase inhibitors5• Reactant for synthesis of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues as antifungal agents6 |
| Melting point | 126-128 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methyl-3-indoleacetic acid used for?
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1-Methyl-3-indoleacetic acid is used as a reactant in various chemical syntheses, including enantioselective preparation of alpha-aryl alkylcarboxylic acids, synthesis of protein kinase inhibitors, stereoselective preparation of delta-lactones, and the creation of antifungal agents and vindorosine analogues.
What is the CAS number and molecular formula?
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The CAS number for 1-Methyl-3-indoleacetic acid is 1912-48-7, and its molecular formula is C11H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Methyl-3-indoleacetic acid with a purity of 98% (assay). This product is supplied for research and laboratory use; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
What are the primary safety hazards associated with this chemical?
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1-Methyl-3-indoleacetic acid is classified as Danger. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment (PPE) such as gloves, eye protection, and respiratory protection should be used. Handle in a well-ventilated area.
How is this chemical packed, shipped, and exported?
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1-Methyl-3-indoleacetic acid is carefully packed according to international shipping regulations to ensure safe transit. Tech Serve Solutions is experienced in global export and can facilitate shipment worldwide.
How can I request a sample or a quote for 1-Methyl-3-indoleacetic acid?
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To request a sample or a quote, please contact our sales team via the website or by telephone. Please specify the quantity required and your delivery location.
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