1-Methyl-2-(2-diphenylphosphinophenyl)-1H-benzoimidazole
1-Methyl-2-(2-diphenylphosphinophenyl)-1H-benzoimidazole (CAS: 1357398-59-4) is a unique organophosphorus compound with the molecular formula C26H21N2P and a molecular weight of 392.43 g/mol. This benzimidazole derivative functions as an efficient phosphine ligand. It is primarily employed in organic synthesis, notably in catalysing challenging cross-coupling reactions like the Suzuki-Miyaura coupling and Buchwald-Hartwig amination, facilitating the formation of complex organic molecules.
Suzuki-Miyaura Coupling
This compound serves as an effective ligand in Suzuki-Miyaura cross-coupling reactions, particularly when coupling aryl mesylates. It promotes efficient carbon-carbon bond formation.
Buchwald-Hartwig Amination
As a phosphine ligand, it is valuable for catalysing Buchwald-Hartwig amination reactions involving aryl chlorides. This application enables the synthesis of aryl amines.
Catalysis in Organic Synthesis
Its phosphine functionality makes it a versatile catalyst component for various organic transformations. It aids in complex molecule construction through advanced synthetic methodologies.
| Molecular weight | 392.43 |
|---|---|
| Empirical formula | C26H21N2P |
| Assay | 95% |
| Storage temperature | 20-25°C |
| Application | Efficient ligand for Suzuki-Miyaura coupling with of aryl mesylates and Buchwald-Hartwig amination with aryl chlorides. |
| Melting point | 166-172 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methyl-2-(2-diphenylphosphinophenyl)-1H-benzoimidazole used for?
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This compound is used as an efficient phosphine ligand in catalytic applications, particularly for Suzuki-Miyaura coupling of aryl mesylates and Buchwald-Hartwig amination of aryl chlorides in organic synthesis.
What are the CAS number and formula for this compound?
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The CAS number is 1357398-59-4, and the empirical formula is C26H21N2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a minimum assay of 95%. It is not specified as USP, BP, or EP grade and is intended for research and laboratory use.
How should 1-Methyl-2-(2-diphenylphosphinophenyl)-1H-benzoimidazole be handled?
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This compound is classified as a Warning, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust and ensure good ventilation (P261, P305 + P351 + P338).
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. This product is shipped and exported in compliance with all relevant international regulations for chemical transport. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or obtain a sample, please visit the Tech Serve Solutions website or contact our sales department directly with your specific requirements.
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