1-[2-[Bis(tert-butyl)phosphino]phenyl]-3,5-diphenyl-1H-pyrazole
1-[2-[Bis(tert-butyl)phosphino]phenyl]-3,5-diphenyl-1H-pyrazole (CAS 628333-86-8) is a phosphine ligand with a molecular weight of 440.56 g/mol. Its complex structure makes it valuable in organic synthesis, particularly as a catalyst in palladium-catalyzed cross-coupling reactions and heterocyclization processes. This compound serves as a key reagent for developing new synthetic methodologies in academic research and industrial chemical development.
- IUPAC
- TrippyPhos
- Synonyms
- TrippyPhos
![1-[2-[Bis(tert-butyl)phosphino]phenyl]-3,5-diphenyl-1H-pyrazole (C29H33N2P) — chemical structure, CAS 628333-86-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F628333-86-8.png&w=3840&q=75)
Palladium-Catalyzed Alkyne Cyclization
This compound acts as an effective ligand in palladium-catalyzed alkyne cyclization reactions, facilitating the formation of complex cyclic structures.
Heterocyclization of Diketones
It serves as a catalyst in the heterocyclization of diketones, enabling the synthesis of various heterocyclic compounds.
Cross-Coupling Reactions
As a phosphine ligand, it is employed in various palladium-catalyzed cross-coupling reactions, enhancing catalytic efficiency and selectivity.
| Molecular weight | 440.56 |
|---|---|
| Empirical formula | C29H33N2P |
| Assay | 96% |
| Application | Catalyst in:• Palladium-catalyzed cross-coupling-alkyne cyclization1• Heterocyclization of diketones2 |
| Melting point | 138-142 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-[2-[Bis(tert-butyl)phosphino]phenyl]-3,5-diphenyl-1H-pyrazole used for?
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It is primarily used as a catalyst ligand in palladium-catalyzed cross-coupling reactions, such as alkyne cyclization, and in the heterocyclization of diketones.
What are the CAS number and molecular formula for this compound?
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The CAS number is 628333-86-8, and the molecular formula is C29H33N2P. The molecular weight is 440.56 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 96%. It is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should this compound be handled safely?
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This compound is classified as Danger. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation.
Is this product available for export and how is it shipped?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals. Please contact us for export and shipping details.
How can I request a sample or a quote?
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To request a sample or a quote, please use the contact form on our website or email our sales department with your specific requirements.
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