1-Methyl-1-propenylmagnesium bromide solution
1-Methyl-1-propenylmagnesium bromide solution (CAS 85676-85-3) is an organometallic reagent with the linear formula CH3CH=C(CH3)MgBr and a molecular weight of 159.31 g/mol. This alkenyl Grignard reagent is supplied as a 0.5 M solution in Tetrahydrofuran (THF). It is primarily utilised in organic synthesis for introducing the 1-methyl-1-propenyl group into target molecules, acting as a versatile building block in complex chemical constructions.
Organometallic Synthesis
As a Grignard reagent, it is employed in nucleophilic addition reactions with carbonyl compounds, epoxides, and other electrophiles. This facilitates the formation of new carbon-carbon bonds, crucial for building molecular complexity in organic chemistry.
Chemical Synthesis Reagent
This compound serves as a valuable intermediate in the synthesis of various organic molecules. Its reactivity allows for the controlled introduction of unsaturated alkyl chains, making it useful in the development of pharmaceuticals and fine chemicals.
Alkenyl Group Transfer
The reagent is specifically designed for the transfer of the 1-methyl-1-propenyl moiety. This is particularly useful in stereoselective synthesis where precise placement of the double bond and its substituents is required.
| Molecular weight | 159.31 |
|---|---|
| Linear formula | CH3CH=C(CH3)MgBr |
| Boiling point | 67 °C |
| Density | 0.934 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -26 °C / -14.8 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-20/21/22-34-37 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methyl-1-propenylmagnesium bromide solution used for?
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1-Methyl-1-propenylmagnesium bromide solution is used as an organometallic reagent in organic synthesis, primarily for introducing the 1-methyl-1-propenyl group into molecules via nucleophilic addition reactions.
What is the CAS number and formula for this compound?
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The CAS number is 85676-85-3, and its linear formula is CH3CH=C(CH3)MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. The specific assay/grade is technical/research grade, and we do not represent it as USP/BP/EP or other pharmacopoeial grades.
What are the key safety considerations for handling 1-Methyl-1-propenylmagnesium bromide solution?
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This solution is highly flammable and reacts violently with water, potentially forming explosive peroxides. It is corrosive and can cause severe skin burns and eye damage, and may cause respiratory irritation. Strict adherence to safety protocols, including the use of appropriate personal protective equipment (gloves, goggles, face shield, respirator) and working in a well-ventilated area or fume hood, is essential. It must be protected from moisture and ignition sources.
How is this chemical packed, shipped, and exported?
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This product is typically packed in specialised containers suitable for flammable and water-reactive substances. Shipping and export are conducted in compliance with all relevant international regulations for hazardous materials (UN 3399, Class 4.3).
How can I request a sample or quote?
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Please contact our sales team directly via our website or by phone to request a sample or a formal quotation for 1-Methyl-1-propenylmagnesium bromide solution.
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