1-Iodo-3,5-bis(trifluoromethyl)benzene
1-Iodo-3,5-bis(trifluoromethyl)benzene (CAS: 328-73-4), with the molecular formula C8H3F6I and a molecular weight of 340.00 g/mol, is a trifluoromethylated iodobenzene. This compound serves as a valuable building block in organic synthesis, particularly for introducing the 3,5-bis(trifluoromethyl)phenyl moiety into complex molecules. It is widely utilised in the development of pharmaceuticals, agrochemicals, and advanced materials.
- Synonyms
- (CF3)2C6H3I
Organic Synthesis Intermediate
This iodinated aromatic compound is a key intermediate in various cross-coupling reactions, such as Suzuki, Stille, and Sonogashira couplings. It enables the facile introduction of the 3,5-bis(trifluoromethyl)phenyl group, a motif found in numerous bioactive molecules and functional materials.
Pharmaceutical Research
The 3,5-bis(trifluoromethyl)phenyl structural unit is present in several drug candidates and active pharmaceutical ingredients. 1-Iodo-3,5-bis(trifluoromethyl)benzene facilitates the synthesis of these complex pharmaceutical agents, contributing to drug discovery and development efforts.
Materials Science
The electron-withdrawing nature of the trifluoromethyl groups makes this compound useful in the synthesis of organic electronic materials. It can be incorporated into polymers or small molecules for applications in organic light-emitting diodes (OLEDs) and other advanced material systems.
Agrochemical Development
Fluorinated aromatic compounds are frequently employed in the design of potent agrochemicals. This building block aids in the creation of new herbicides, insecticides, and fungicides, leveraging its unique electronic properties.
| Molecular weight | 340.00 |
|---|---|
| Linear formula | (CF3)2C6H3I |
| Assay | 98% |
| Boiling point | 59-61 °C/10 mmHg(lit.) |
| Density | 1.919 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 74 °C / 165.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Iodo-3,5-bis(trifluoromethyl)benzene used for?
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1-Iodo-3,5-bis(trifluoromethyl)benzene is primarily used as a building block in organic synthesis, especially for introducing the 3,5-bis(trifluoromethyl)phenyl group into pharmaceutical intermediates, agrochemicals, and materials science research.
What is the CAS number and formula for 1-Iodo-3,5-bis(trifluoromethyl)benzene?
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The CAS number is 328-73-4 and the linear formula is (CF3)2C6H3I.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Iodo-3,5-bis(trifluoromethyl)benzene with a purity of 98% assay. This is a technical grade suitable for research and synthesis; TSS does not represent this product as USP, BP, or EP grade.
How should 1-Iodo-3,5-bis(trifluoromethyl)benzene be handled?
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This compound is an irritant to the skin, eyes, and respiratory system (H315, H319, H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and use in a well-ventilated area or fume hood. Avoid breathing vapours.
How is 1-Iodo-3,5-bis(trifluoromethyl)benzene shipped and exported?
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1-Iodo-3,5-bis(trifluoromethyl)benzene is carefully packaged and exported globally by Tech Serve Solutions, adhering to all relevant shipping and hazardous materials regulations.
How can I request a quote or sample of 1-Iodo-3,5-bis(trifluoromethyl)benzene?
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To request a quote or a sample, please contact our sales team via the website or by phone, providing your specific requirements and shipping details.
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