1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester
1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester (CAS: 864754-16-5, C13H21BN2O4) is an organoboronic ester with a molecular weight of 280.13. This compound serves as a valuable building block in organic synthesis, particularly for cross-coupling reactions. It is widely employed in the development of novel pharmaceutical intermediates and complex organic molecules, owing to the versatile reactivity of the boronate ester moiety in conjunction with the pyrazole heterocycle.
- IUPAC
- Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate
Organic Synthesis Intermediate
Utilised as a key reagent in Suzuki-Miyaura cross-coupling reactions to introduce pyrazole-containing fragments into target molecules. This facilitates the construction of complex molecular architectures relevant to drug discovery and materials science.
Pharmaceutical Research
Serves as a critical intermediate in the synthesis of potential drug candidates and biologically active compounds. Its pyrazole core is a common feature in many pharmacologically relevant structures.
Heterocyclic Chemistry
A versatile building block for the preparation of diverse substituted pyrazoles, which are important scaffolds in medicinal chemistry and agrochemicals. The pinacol ester provides stability and ease of handling compared to free boronic acids.
| Molecular weight | 280.13 |
|---|---|
| Empirical formula | C13H21BN2O4 |
| Assay | 97% |
| Refractive index | n20/D 1.4814 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester used for?
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This compound is primarily used as an intermediate in organic synthesis, especially for Suzuki-Miyaura cross-coupling reactions to create complex molecules, including pharmaceutical intermediates and novel organic compounds.
What is the CAS number and molecular formula?
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The CAS number is 864754-16-5, and the molecular formula is C13H21BN2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should this chemical be handled safely?
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This compound is a Warning hazard (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Always use appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation or use a suitable respirator.
Is this product packed and shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be packed and exported worldwide.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales department through the website or by phone, providing the product name and CAS number.
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