1-Chloroethyl chloroformate
1-Chloroethyl chloroformate (CAS 50893-53-3), with the linear formula CH3CHClOCOCl and a molecular weight of 142.97 g/mol, is a reactive organic compound. It serves as a valuable building block and reagent in chemical synthesis. Its primary applications involve N-demethylation reactions for drug metabolite analysis and the cleavage of protective groups from amines and alcohols.
- IUPAC
- ACE-Cl
N-Demethylation for Drug Analysis
1-Chloroethyl chloroformate is employed in the N-demethylation of tertiary amines, enabling the production of drug metabolite reference materials crucial for forensic toxicology and the determination of multiple drugs of abuse in biological fluids.
Catalyst in Desilylation Reactions
This compound acts as a catalyst to achieve chemoselective desilylation of silyl-protected alcohols, a key step in multi-step organic synthesis where precise deprotection is required.
Cleavage of Benzhydryl Groups
It functions as a reagent to effectively cleave benzhydryl protecting groups from amine functionalities, facilitating further synthetic transformations.
| Molecular weight | 142.97 |
|---|---|
| Linear formula | CH3CHClOCOCl |
| Assay | 98% |
| Boiling point | 118-119 °C(lit.) |
| Density | 1.325 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.422(lit.) |
| Vapour pressure | 3.25 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | 1-Chloroethyl chloroformate was used:• for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection1• as catalyst in chemoselective desilylation of silyl-protected alcohols2• as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications3• as reagent to cleave benzhydryl groups from amines4 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 40 °C / 104 °F |
| Transport (UN / ADR) | UN 2742 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-22-23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Chloroethyl chloroformate used for?
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1-Chloroethyl chloroformate is used in N-demethylation reactions for drug metabolite analysis and forensic toxicology, as a catalyst in chemoselective desilylation of silyl-protected alcohols, and as a reagent to cleave benzhydryl groups from amines.
What are the CAS number and chemical formula for 1-Chloroethyl chloroformate?
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The CAS number is 50893-53-3, and its linear formula is CH3CHClOCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Chloroethyl chloroformate with an assay of 98%. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product specifications.
How should 1-Chloroethyl chloroformate be handled safely?
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1-Chloroethyl chloroformate is a flammable liquid and vapour (H226), harmful if swallowed (H302), causes severe skin burns and eye damage (H314), and is toxic if inhaled (H331). It requires the use of full-face respirators, protective gloves, goggles, and face shields. Handle in a well-ventilated area, away from ignition sources. Store at 2-8°C.
Is 1-Chloroethyl chloroformate shipped internationally by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1-Chloroethyl chloroformate.
How can I request a sample or quote for 1-Chloroethyl chloroformate?
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Please contact our sales team via the website or by telephone to request a sample or a formal quotation for 1-Chloroethyl chloroformate.
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