1-Chloro-4-fluorobenzene
1-Chloro-4-fluorobenzene (CAS: 352-33-0, Formula: ClC6H4F) is a halogenated aromatic compound with a molecular weight of 130.55 g/mol. It serves as a versatile building block in organic synthesis. This compound is primarily utilised in the chemical industry for the development of various organic intermediates and fine chemicals, contributing to advancements in material science and chemical research.
Organic Synthesis Intermediate
1-Chloro-4-fluorobenzene is a key intermediate in the synthesis of more complex organic molecules. Its specific substitution pattern allows for regioselective reactions, making it valuable in multi-step synthetic pathways.
Pharmaceutical Precursor
This compound can be employed as a starting material or intermediate in the production of active pharmaceutical ingredients (APIs). The presence of both chlorine and fluorine atoms offers versatile reaction sites for drug discovery and development.
Agrochemical Development
It finds application in the synthesis of agrochemicals, contributing to the development of new pesticides, herbicides, and fungicides. The fluorinated aromatic structure can impart desirable properties to the final agrochemical products.
Material Science
1-Chloro-4-fluorobenzene can be used in the synthesis of specialised polymers and materials. Its unique electronic and structural properties can be incorporated into advanced materials for various technological applications.
| Molecular weight | 130.55 |
|---|---|
| Linear formula | ClC6H4F |
| Assay | 98% |
| Boiling point | 129-130 °C(lit.) |
| Density | 1.226 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.495(lit.) |
| Melting point | −27-−26 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 29 °C / 84.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Chloro-4-fluorobenzene used for?
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1-Chloro-4-fluorobenzene is primarily used as an intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialised materials.
What is the CAS number and formula for 1-Chloro-4-fluorobenzene?
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The CAS number is 352-33-0, and the chemical formula is ClC6H4F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies 1-Chloro-4-fluorobenzene with an assay of 98%. This product is generally supplied as a technical or research grade, and TSS does not represent it as USP, BP, or EP grade unless explicitly stated.
How should 1-Chloro-4-fluorobenzene be handled safely?
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1-Chloro-4-fluorobenzene is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
Is 1-Chloro-4-fluorobenzene a controlled substance?
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Based on the provided data, 1-Chloro-4-fluorobenzene is not indicated as a controlled substance.
How is 1-Chloro-4-fluorobenzene packed and exported?
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1-Chloro-4-fluorobenzene is typically packed in compliance with transport regulations for hazardous materials, such as UN 1993. TSS handles the export of chemicals adhering to all international shipping standards.
How can I request a quote or sample for 1-Chloro-4-fluorobenzene?
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To request a quote or sample, please contact the TSS sales team through our website or by phone, providing your specific requirements and shipping details.
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