1-Bromocarbonyl-1-methylethyl acetate
1-Bromocarbonyl-1-methylethyl acetate (CAS: 40635-67-4), with the linear formula CH₃COOC(CH₃)₂COBr, has a molecular weight of 209.04 g/mol. This acid halide serves as a valuable reagent in organic synthesis. Its primary applications include the deoxygenation of vicinal diols and the preparation of dideoxynucleosides, notably 2′,3′-dideoxycytidine, from their corresponding ribo series precursors.
- IUPAC
- α-Acetoxyisobutyryl bromide,2-Acetoxy-2-methylpropionyl bromide
- Synonyms
- α-Acetoxyisobutyryl bromide2-Acetoxy-2-methylpropionyl bromide
Deoxygenation of Vicinal Diols
1-Bromocarbonyl-1-methylethyl acetate acts as a reagent for the efficient deoxygenation of vicinal diols in organic synthesis, enabling the transformation of hydroxyl groups into hydrogen atoms.
Nucleoside Synthesis
This compound is employed in the preparation of dideoxynucleosides, such as 2′,3′-dideoxycytidine, by facilitating the removal of oxygen atoms from the ribose sugar moiety.
Organic Synthesis Building Block
As an acid halide and organic building block, it can be utilised in various synthetic pathways requiring the introduction of an acetoxyisobutyryl group or related functionalities.
| Molecular weight | 209.04 |
|---|---|
| Linear formula | CH3COOC(CH3)2COBr |
| Assay | 96% |
| Boiling point | 75-77 °C/12 mmHg(lit.) |
| Density | 1.431 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.457(lit.) |
| Storage temperature | 2-8°C |
| Application | Reagent for deoxygenation of vicinal diols, as well as in the preparation of 2′,3′-dideoxycytidine and other dideoxy and deoxynucleosides from the corresponding ribo series.1 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromocarbonyl-1-methylethyl acetate used for?
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1-Bromocarbonyl-1-methylethyl acetate is used as a reagent for the deoxygenation of vicinal diols and in the preparation of dideoxynucleosides, including 2′,3′-dideoxycytidine.
What is the CAS number and chemical formula?
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The CAS number is 40635-67-4, and the linear formula is CH₃COOC(CH₃)₂COBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromocarbonyl-1-methylethyl acetate with a purity of 96% (assay). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-Bromocarbonyl-1-methylethyl acetate be handled safely?
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This compound is corrosive and may cause respiratory irritation. It reacts violently with water. Handle with extreme care, using appropriate personal protective equipment including a full-face respirator, gloves, and eye protection, and avoid contact with moisture. Refer to the Safety Data Sheet for full details.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1-Bromocarbonyl-1-methylethyl acetate.
How can I request a quote or sample?
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Please contact our sales department through the website or by phone to request a quote or a sample of 1-Bromocarbonyl-1-methylethyl acetate.
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