1-Bromo-4-fluorobenzene
1-Bromo-4-fluorobenzene (CAS 460-00-4), with the chemical formula BrC6H4F and a molecular weight of 175.00 g/mol, is a halogenated aromatic compound. It serves as a key building block in organic synthesis. This versatile intermediate is primarily employed in the pharmaceutical and agrochemical industries for the creation of complex molecules. Its specific reactivity makes it valuable for introducing the 4-fluorobromophenyl moiety into target structures.
Pharmaceutical Intermediate
1-Bromo-4-fluorobenzene is extensively used in the synthesis of active pharmaceutical ingredients (APIs). It allows for the regioselective introduction of fluorinated phenyl groups, which can enhance the metabolic stability and bioavailability of drug candidates.
Agrochemical Synthesis
This compound functions as a crucial intermediate in the development of novel pesticides and herbicides. The presence of both bromine and fluorine atoms facilitates specific synthetic routes to create effective crop protection agents.
Material Science Research
It is employed in the research and development of advanced materials, including polymers and liquid crystals. The unique electronic properties imparted by the halogen substituents can be exploited to tune material characteristics.
Organic Synthesis Reagent
As a general organic building block, 1-Bromo-4-fluorobenzene is valuable for various cross-coupling reactions, such as Suzuki, Stille, and Heck couplings, enabling the construction of intricate organic frameworks.
| Molecular weight | 175.00 |
|---|---|
| Linear formula | BrC6H4F |
| Assay | 99% |
| Boiling point | 150 °C(lit.) |
| Density | 1.593 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.527(lit.) |
| Melting point | −16 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 53 °C / 127.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-4-fluorobenzene used for?
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1-Bromo-4-fluorobenzene is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and in material science research.
What is the CAS number and chemical formula for 1-Bromo-4-fluorobenzene?
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The CAS number is 460-00-4, and the chemical formula is BrC6H4F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromo-4-fluorobenzene with an assay of 99%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
How should 1-Bromo-4-fluorobenzene be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields, faceshields, and gloves. Ensure adequate ventilation and use a suitable respirator filter (e.g., type ABEK). It is a flammable liquid and vapour (H226), harmful if inhaled (H332), and causes skin (H315), eye (H319), and respiratory irritation (H335).
How is 1-Bromo-4-fluorobenzene packed and exported?
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This chemical is packed according to UN 1993 C3/PGIII regulations for safe transport and is available for global export.
How can I request a quote or sample?
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To request a quote or sample, please contact the TSS sales department via our website or by phone, providing your specific requirements.
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